Table 1 CTC detection and clinical characteristics of early breast cancer patients
Patients enrolled | Â | AdnaTest | CK19 | Multiplex | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | All number (%) | Positive number (%) | Negative number (%) | P a | Positive number (%) | Negative number (%) | P a | Positive number (%) | Negative number (%) | P a |
| Â | 254 (100) | 42 (16.5) | 212 (83.5) | Â | 36 (14.2) | 218 (85.8) | Â | 58 (22.8) | 196 (77.2) | Â |
Age, years | Â | Â | Â | 0.398 | Â | Â | 0.383 | Â | Â | 0.614 |
≥ 61 | 130 (51.2) | 24 (18.5) | 106 (81.5) |  | 16 (12.3) | 114 (87.7) |  | 28 (21.5) | 102 (78.5) |  |
< 61 | 124 (48.8) | 18 (14.5) | 106 (85.5) | Â | 20 (16.1) | 104 (83.9) | Â | 30 (24.2) | 94 (75.8) | Â |
Staging | Â | Â | Â | 0.827 | Â | Â | 0.343 | Â | Â | Â |
   Tx | 1 (0.39) | 0 (0) | 1 (100) |  | 0 (0) | 1 (100) |  | 0 (0) | 1 (100) |  |
   is | 8 (3.15) | 2 (25.0) | 6 (75.2) |  | 0 (0) | 8 (100) |  | 1 (12.5) | 7 (87.5) |  |
   To | 6 (2.36) | 1 (16.7) | 5 (83.3) |  | 0 (0) | 6 (100) |  | 2 (33.3) | 4 (66.7) |  |
   I/II | 206 (81.1) | 29 (14.1) | 177 (85.9) |  | 34 (16.5) | 172 (83.5) |  | 48 (23.3) | 158 (76.7) |  |
   III/IV | 19 (7.48) | 4 (21.1) | 15 (78.9) |  | 1 (5.26) | 18 (94.7) |  | 4 (21.0) | 15 (79.0) |  |
   Unknown | 14 (5.51) |  |  |  |  |  |  |  |  |  |
Grading | Â | Â | Â | 0.386 | Â | Â | 0.822 | Â | Â | Â |
   1 | 45 (17.7) | 5 (11.1) | 40 (88.9) |  | 6 (13.3) | 39 (86.7) |  | 12 (26.7) | 33 (73.3) | 0.816 |
   2 | 105 (41.3) | 19 (18.1) | 86 (81.9) |  | 17 (16.2) | 88 (83.8) |  | 23 (21.9) | 82 (78.1) |  |
   3 | 83 (32.7) | 10 (12.1) | 73 (88.0) |  | 11 (13.2) | 72 (86.8) |  | 19 (22.9) | 64 (77.1) |  |
   Unknown | 21 (8.37) |  |  |  |  |  |  |  |  |  |
Lymph nodes | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   N0 | 130 (51.2) | 17 (13.1) | 113 (86.9) | 0.099 | 23 (17.7) | 107 (82.3) | 0.450 | 31 (23.8) | 99 (76.2) | 0.871 |
   N1 | 54 (21.3) | 9 (16.7) | 45 (83.3) |  | 6 (11.1) | 48 (88.9) |  | 15 (27.8) | 39 (72.2) |  |
   N2 | 15 (5.91) | 3 (20.0) | 12 (80.0) |  | 2 (13.3) | 13 (86.7) |  | 3 (20.0) | 12 (80.0) |  |
   N3 | 6 (2.36) | 3 (50.0) | 3 (50.0) |  | 2 (33.3) | 4 (66.7) |  | 1 (16.7) | 5 (83.3) |  |
   Unknown | 49 (19.3) |  |  |  |  |  |  |  |  |  |
Histology | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Ductal | 175 (68.9) | 23 (13.1) | 152 (86.9) | 0.251 | 23 (13.1) | 152 (86.9) | 0.201 | 39 (22.3) | 136 (77.7) |  |
   Lobular | 35 (13.8) | 7 (20.0) | 28 (80.0) |  | 9 (25.7) | 26 (74.3) |  | 12 (34.3) | 23 (65.7) |  |
   Ductal/Lobular | 5 (1.97) | 2 (40.0) | 3 (60.0) |  | 1 (20.0) | 4 (80.0) |  | 0 (0) | 5 (100) |  |
   Other | 24 (9.45) | 5 (20.8) | 19 (79.2) |  | 2 (8.3) | 22 (91.7) |  | 4 (16.7) | 20 (83.3) |  |
   Unknown | 15 (5.91) |  |  |  |  |  |  |  |  |  |
ER | Â | Â | Â | 0.553 | Â | Â | 0.275 | Â | Â | 0.581 |
   Positive | 179 (70.5) | 28 (15.6) | 151 (84.4) |  | 29 (16.2) | 150 (83.8) |  | 40 (22.3) | 139 (77.7) |  |
   Negative | 58 (22.8) | 11 (19.0) | 47 (81.0) |  | 6 (10.3) | 52 (89.7) |  | 15 (25.9) | 43 (74.1) |  |
   Unknown | 17 (6.7) |  |  |  |  |  |  |  |  |  |
PR | Â | Â | Â | 0.474 | Â | Â | 0.184 | Â | Â | 0.361 |
   Positive | 175 (68.9) | 27 (15.4) | 148 (84.6) |  | 29 (16.6) | 146 (83.4) |  | 38 (21.7) | 137 (78.3) |  |
   Negative | 62 (24.4) | 12 (19.4) | 50 (80.6) |  | 6 (9.7) | 56 (90.3) |  | 17 (27.4) | 45 (72.6) |  |
   Unknown | 17 (6.7) |  |  |  |  |  |  |  |  |  |
HER2 | Â | Â | Â | Â | Â | Â | 0.725 | Â | Â | 0.397 |
   Positive | 38 (15.0) | 7 (18.4) | 31 (81.6) | 0.639 | 5 (13.2) | 33 (86.8) |  | 11 (29.0) | 27 (71.0) |  |
   Negative | 195 (76.8) | 30 (15.4) | 165 (84.6) |  | 30 (15.4) | 165 (84.6) |  | 44 (22.6) | 151 (77.4) |  |
   Unknown | 21 (8.27) |  |  |  |  |  |  |  |  |  |