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Table 3 Odds ratios and 95% confidence intervals for breast cancer risk according to season-adjusted circulating levels of 25(OH)D (by quintiles and as a continuous variable)

From: Circulating levels of 25-hydroxyvitamin D and risk of breast cancer: a nested case-control study

 

Quintiles

Continuous

 

1

2

3

4

5

P trend

OR (95% CI)a

Pvalue

Both cohorts

        

   Cases/controls

311/589

362/588

309/588

315/588

288/587

   

   Unadjusted model

1.0 (ref)

1.18 (0.97, 1.43)

0.99 (0.81, 1.21)

1.02 (0.84, 1.24)

0.93 (0.76, 1.14)

0.18

0.94 (0.84, 1.06)

0.31

   Adjusted modelb

1.0 (ref)

1.16 (0.95, 1.42)

1.00 (0.81, 1.22)

1.04 (0.85, 1.27)

0.94 (0.76, 1.16)

0.30

0.95 (0.84, 1.08)

0.44

   Adjusted modelc

1.0 (ref)

1.16 (0.95, 1.42)

0.99 (0.81, 1.21)

1.03 (0.84, 1.27)

0.94 (0.76, 1.16)

0.27

0.95 (0.84, 1.07)

0.40

NYUWHS

        

   Cases/controls

191/329

190/328

176/329

170/328

166/328

   

   Unadjusted model

1.0 (ref)

0.99 (0.76, 1.29)

0.92 (0.71, 1.20)

0.89 (0.69, 1.16)

0.86 (0.66, 1.12)

0.18

0.91 (0.79, 1.05)

0.21

   Adjusted modelb

1.0 (ref)

0.98 (0.75, 1.28)

0.94 (0.72, 1.23)

0.92 (0.70, 1.21)

0.88 (0.67, 1.16)

0.31

0.93 (0.80, 1.08)

0.34

   Adjusted modelc

1.0 (ref)

1.00 (0.76, 1.31)

0.95 (0.73, 1.24)

0.93 (0.71, 1.22)

0.90 (0.68, 1.19)

0.37

0.94 (0.81, 1.09)

0.42

NSMSC

        

   Cases/controls

120/260

172/260

133/259

145/260

122/259

   

   Unadjusted model

1.0 (ref)

1.47 (1.09, 1.97)

1.10 (0.81, 1.49)

1.22 (0.90, 1.64)

1.03 (0.75, 1.40)

0.62

1.00 (0.82, 1.23)

0.99

   Adjusted modelb

1.0 (ref)

1.48 (1.08, 2.01)

1.09 (0.79, 1.49)

1.26 (0.92, 1.72)

1.05 (0.76, 1.46)

0.74

1.02 (0.82, 1.26)

0.89

   Adjusted modelc

1.0 (ref)

1.46 (1.07, 1.99)

1.08 (0.79, 1.48)

1.24 (0.91, 1.70)

1.04 (0.75, 1.45)

0.71

1.01 (0.81, 1.26)

0.94

  1. aOdds ratio (OR) for a doubling in 25(OH)D level. bAdjusted for age at menarche (continuous), age at first birth/parity (≤ 20, 21-25, 26-30, > 30 years, nulliparous), family history of breast cancer (no or yes), body mass index (continuous), hormone replacement therapy use (never or ever), and alcohol consumption (continuous). cAdjusted for physical activity and multivitamin use in addition to variables in footnote a. 25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; NSMSC, Northern Sweden Mammary Screening Cohort; NYUWHS, New York University Women's Health Study; ref, reference.
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Breast Cancer Research

ISSN: 1465-542X

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