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Table 3 Correlation between diffuse optical spectroscopic imaging parameters andfibroglandular density measured with magnetic resonance imaging for subjects atbaseline and at time points during chemotherapy

From: Optical imaging correlates with magnetic resonance imaging breast density and revealscomposition changes during neoadjuvant chemotherapy

  Baseline (n= 12) ~25 days (n= 10)
Mean, 24.8 ± 5.5
~82 days (n= 7)
Mean, 82.4 ± 11.9
  R P R P r P
Water 0.843 <0.001 0.675 0.032 0.405 0.367
Lipid -0.707 0.010 -0.462 0.179 -0.018 0.970
ctO2Hb 0.557 0.060 0.647 0.043 0.464 0.294
ctHHb 0.785 0.003 0.399 0.253 0.705 0.077
ctTHb 0.597 0.040 0.644 0.045 0.599 0.155
stO2 0.196 0.543 0.240 0.505 0.012 0.979
TOI 0.891 <0.001 0.541 0.107 0.593 0.160
Scat. power 0.205 0.523 0.143 0.694 0.265 0.566
  1. Bold values indicate statistical significance at the 0.05 level.ctO2Hb, oxyhemoglobin concentration; ctHHb, deoxyhemoglobinconcentration; ctTHb, total hemoglobin concentration; stO2, tissueoxygen saturation; TOI, tissue optical index; Scat. power, optical scatteringpower.