Diffuse optical spectroscopic imaging (DOSI) measurement schematic. Atwo-dimensional map of functional properties is generated by measuring broadbandabsorption and scattering spectra in a grid pattern. On the left is a grid (10 mm)in which each dot represents a DOSI measurement point. The middle is a map oflipid concentration (actual breast data) generated from the measured spectra onthe right. Note that the areola region (A) has much less lipidconcentration and overall higher optical absorption compared with the rest of thebreast (B) because of the higher concentration of water and hemoglobin infibroglandular tissue.