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Table 1 Patients, relapse and follow-up in women with breast cancer by use of digoxin

From: Breast cancer in women using digoxin: tumor characteristics and relapse risk

 

Patients, number (%)

P-value1

Relapse, number

Total person-years of follow-up

 

Digoxin use at breast cancer

 

Digoxin use at breast cancer

Users of digoxin

Non-users of digoxin

 

Yes

No

 

Yes

No

  

Total

369 (100)

34,085 (100)

 

45

5,061

1,487

148,418

Age, years

       

20 to 54

12 (3.2)

13,593 (39.9)

<0.001

2

2,217

68

63,050

55 to 60

36 (9.8)

7,097 (20.8)

 

5

1,059

165

31,240

61 to 69

163 (44.2)

9,764 (28.6)

 

20

1,288

641

39,832

70 to 74

158 (42.8)

3,631 (10.7)

 

18

497

614

14,296

Year of onset

1995 to 1999

164 (44.4)

10,612 (31.1)

<0.001

29

2,563

810

64,854

2000 to 2004

111 (30.1)

12,250 (35.9)

 

12

1,861

512

63,785

2005 to 2008

94 (25.5)

11,223 (32.9)

 

4

637

165

19,779

Tumor size

No information

5 (1.4)

361 (1.1)

0.602

1

58

13

1,653

≤2 cm

226 (62.1)

20,180 (59.8)

0.653

22

2,236

945

90,817

2 to 5 cm

127 (34.9)

12,361 (36.7)

 

19

2,403

485

51,454

>5 cm

11 (3.0)

1,183 (3.5)

 

3

364

45

4,495

Tumor-positive nodes

No information

3 (0.8)

45 (0.1)

0.015

0

5

10

96

0

216 (59.1)

18,062 (53.1)

0.139

20

1,865

912

82,010

1 to 3

97 (26.5)

10,305 (30.3)

 

8

1,449

399

45,639

4 to 9

36 (9.8)

3,619 (10.6)

 

11

977

120

14,095

≥10

17 (4.6)

2,054 (6.0)

 

6

765

47

6,578

Histology grading

No information

8 (2.2)

608 (1.8)

0.580

2

77

24

2,899

Ductal grade I

118 (32.7)

8,602 (25.7)

0.004

13

926

495

40,317

Ductal grade II to III

172 (47.7)

18,652 (55.7)

 

24

3,199

605

76,710

Non-ductal

71 (19.7)

6,223 (18.6)

 

6

859

363

28,492

Estrogen receptor

No information

14 (3.8)

1,051 (3.1)

0.446

1

239

57

6,303

Positive

303 (85.4)

25,956 (78.6)

0.002

38

3,473

1,262

111,747

Negative

52 (14.6)

7,078 (21.4)

 

6

1,349

168

30,368

  1. 1Chi2 tests for comparison of group with no information to those with information, and heterogeneity among groups within strata with known data.