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Table 5 Sensitivity and specificity of breast cancer detection with different marker combinations

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

  Sensitivity in
breast cancer
Specificity in healthy and benign breast disease controls Pvalueb AUC (95% CI) PPV NPV
Genea Methylation
positive
% Methylation
negative
%    % %
RASSF1A
ITIH5
75 of 138 54 127 of 174 73 7.8 × e-6 0.647 (0.585-0.709) 61 67
RASSF1A
DKK3
82 of 138 59 131 of 174 75 1.6 × e-8 0.686 (0.626-0.747) 66 70
DKK3
ITIH5
55 of 138 40 164 of 174 94 1.6 × e-7 0.673 (0.611-0.735) 85 66
RASSF1A
DKK3
ITIH5
92 of 138 67 125 of 174 72 1.3 × e -10 0.712 (0.653-0.770) 65 73
  1. aEither gene methylated. bFisher Exact test at a two-sided significance level of 0.05. AUC, area under the curve; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.