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Table 3 Sensitivity and specificity of serum-based detection of aberrantly methylated genes in the test set

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

  Sensitivity in
breast cancer
Specificity in
healthy controls
Specificity in
benign breast diseases
Gene Methylation
positive
% Methylation
negative
% Methylation
negative
%
ITIH5 27 of 112 24 96 of 102 94 20 of 20 100
DKK3 37 of 112 33 101 of 102 99 20 of 20 100
WIF1 39 of 112 35 97 of 102 95 15 of 20 75
SFRP1 12 of 112 11 92 of 102 90 17 of 20 85
SFRP2 21 of 112 19 90 of 102 88 18 of 20 90
SFRP5 9 of 112 8 n.d.   n.d.  
DKK3/ITIH5 a 46 of 112 41 95 of 102 93 20 of 20 100
  1. aEither gene methylated. n.d., not done.