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Table 3 Sensitivity and specificity of serum-based detection of aberrantly methylated genes in the test set

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

 

Sensitivity in

breast cancer

Specificity in

healthy controls

Specificity in

benign breast diseases

Gene

Methylation

positive

%

Methylation

negative

%

Methylation

negative

%

ITIH5

27 of 112

24

96 of 102

94

20 of 20

100

DKK3

37 of 112

33

101 of 102

99

20 of 20

100

WIF1

39 of 112

35

97 of 102

95

15 of 20

75

SFRP1

12 of 112

11

92 of 102

90

17 of 20

85

SFRP2

21 of 112

19

90 of 102

88

18 of 20

90

SFRP5

9 of 112

8

n.d.

 

n.d.

 

DKK3/ITIH5 a

46 of 112

41

95 of 102

93

20 of 20

100

  1. aEither gene methylated. n.d., not done.