Figure 5From: Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein responseKnockdown of PERK, ATF4 and LAMP3 reduces cell migration under hypoxic conditions in gap closure assays. (A-F) Effect of hypoxia (1% O2) in combination with transient knockdown of PERK, ATF4 or LAMP3 in MDA-MB-231 cells on cell migration in a gap closure assay. Results are from two representative experiments. ATF4, activating transcription factor 4; LAMP3, lysosomal-associated membrane protein 3; PERK, PKR-like endoplasmic reticulum kinase.Back to article page