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Table 3 Associations of categorical and continuous percent density analysis from raw full-field digital mammography (FFDM) representation with breast cancer (n = 180 case and matched control pairs).

From: Comparison of percent density from raw and processed full-field digital mammography data

Quartile PDraw

Case

N= 180

Unadjusted OR (95% CI)

BMI adjusted OR (95% CI)

BMI, BA adjusted OR (95% CI)

BMI, BA, menopause adjusted OR (95% CI)

1

26

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

2

49

2.21 (1.07, 4.55)

2.55 (1.20, 5.42)

2.60 (1.21, 5.55)

2.83 (1.30, 6.16)

3

47

2.17 (1.07, 4.40)

3.12 (1.44, 6.76)

3.15 (1.45, 6.84)

3.45 (1.55, 7.65)

4

58

2.70 (1.32, 5.49)

4.69 (2.08, 10.58)

4.85 (2.13, 11.07)

5.17 (2.24, 11.96)

BMIa

 

n/a

1.56 (1.22, 1.99)

1.49 (1.13, 1.97)

1.46 (1.10, 1.93)

BAa

 

n/a

n/a

1.09 (0.83, 1.44)

1.11 (0.84, 1.48)

Menopauseb

 

n/a

n/a

n/a

2.42 (1.00, 5.86)

AUCc

 

0.568

0.631

0.634

0.641

Continuous PDraw

Unadjusted OR (95% CI)

BMI adjusted OR (95% CI)

BMI, BA adjusted OR (95% CI)

BMI, BA, menopause adjusted OR (95% CI)

PDa

1.38 (1.07, 1.77)

1.76 (1.31, 2.37)

1.79 (1.33, 2.43)

1.79 (1.32, 2.42)

BMIa

n/a

1.60 (1.25, 2.06)

1.52 (1.15, 2.01)

1.48 (1.12, 1.97)

BAa

n/a

n/a

1.12 (0.85, 1.48)

1.13 (0.85, 1.50)

Menopauseb

n/a

n/a

n/a

2.06 (0.87, 4.89)

AUCc

0.571

0.638

0.641

0.655

  1. aThe ORs for BMI (kg/m2) and BA (cm2), and PD (continuous models) are cited in per standard deviation increase; bfor the binary menopausal variable, pre-menopausal status is the reference; cAUC is a measure of discriminatory accuracy. AUC, area under the receiver operating characteristic curve; BA, breast area; BMI, body mass index; CI, confidence interval; PD, percent density; OR, odds ratio.