Table 1 Basic characteristics of relatives and index patients from BRCA positive and negative families.

Number of patients

6,235

6,230

Mutation status, number of patients

   BRCA1 pathogenic mutation

213

1,154

   BRCA2 pathogenic mutation

106

575

   BRCA negative

4,326

4,501

   not tested, BRCA1 family

1,046

-

   not tested, BRCA2 family

544

-

Patients with contralateral breast cancer

   patients from BRCA1 families

193

304

   patients from BRCA2 families

56

84

   patients from BRCA negative families

253

349

Median year of birth (IQR)

   patients from BRCA1 families

1,943 (1933-1955)

1,960 (1952-1968)

   patients from BRCA2 families

1,939 (1928-1952)

1,957 (1945-1965)

   patients from BRCA negative families

1,936 (1926-1946)

1,955 (1944-1964)

Median age at first breast cancer (IQR)

   patients from BRCA1 families

43.5 (37.5-51.5)

38.2 (32.8-44.4)

   patients from BRCA2 families

48.1 (40.4-58.5)

42.5 (36.4-49.4)

   patients from BRCA negative families

53.6 (45.3-63.9)

44.9 (37.9-51.4)

Median age at contralateral breast cancer (IQR)

   patients from BRCA1 families

47.7 (40.1-55.5)

43.5 (37.7-50.5)

   patients from BRCA2 families

53.1 (44.7-62.6)

47.9 (42.7-55.7)

   patients from BRCA negative families

56.0 (48.5-66.6)

51.6 (45.3-59.0)