Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes

Breast Cancer Research

Table 2 Patient and tumor characteristics of ductal carcinoma in situ (DCIS) cohort

ID	Menopausal status^a	DCIS grade	ER status	PR status	Activin A score^c	Telo-FISH^d	γH2AX score	COX-2 score-	αSMA score	CD31 score	Immune infiltrate score^e
96	Post	3	+	+	Low	High	Low	Low	Low	Low	Low
52	Pre/peri	2	+	+	Low	High	Low	Low	Low	Low	Low
13	Post	2	+	+	Low	High	Low	Low	Low	High	Low
19	Post	3	-	-	Low	High	Low	Low	High	Low	Low
50	Pre/peri	1	+	+	Low	High	High	Low	Low	Low	Low
10	Pre/peri	2	+	+	Low	Low	Low	Low	Low	Low	Low
69	Post	3	+	+	Low	ND	Low	Low	Low	Low	High
28	Pre/peri	3	+	Unk^b	Low	High	High	High	Low	High	High
3	Pre/peri	3	+	+	High	High	High	Low	High	High	High
63	Post	3	-	-	High	ND	High	High	Low	High	High
47	Post	2	+	+	High	ND	High	High	High	High	High
84	Post	3	Unk^b	Unk	High	Low	High	High	High	Low	High
15	Pre/peri	3	+	+	High	Low	High	High	High	High	High
12	Post	3	-	-	High	Low	High	High	High	High	High
66	Pre/peri	2	+	+	High	Low	High	High	High	High	High
9	Post	3	+	+	High	Low	High	High	High	High	High
Sum ^f	Post = 8 Pre/peri = 7	G3 = 10 G2 = 5 G1 = 1	Pos = 12 Neg = 3 Unk = 1	Pos = 11 Neg = 3 Unk = 2	High = 8 Low = 8	High = 7 Low = 6 ND = 3	High = 10 Low = 6	High = 8 Low = 7	High = 8 Low = 8	High = 9 Low = 7	High = 10 Low = 6

^aPre- or perimenopausal status (pre/peri) or postmenopausal (post) status was self-reported. ^bUnknown result (Unk). ^cProtein expression (activin A, γH2AX, COX-2, αSMA, and CD31) was stratified into two groups, as described in Methods. ^dTelomere-specific fluorescence in situ hybridization (Telo-FISH) intensity was stratified into two groups, as described in Methods. Cases in which telomere intensity could not be determined are shown (ND). ^eDegree of immune cell infiltrate was evaluated on H&E slides and stratified into two groups, as described in Methods. ^fSummary of cohort showing the number of cases in each category (ethnicity, mean age at diagnosis, menopausal status, DCIS grade, ER and PR status, Activin A, γH2AX, COX-2, αSMA, and CD31 protein expression and immune infiltration).

ISSN: 1465-542X