Figure 8From: Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumorsPositive estrogen receptor status in breast tumors significantly associated with lower levels of TrxR1 expression. (A) TrxR1, estrogen receptor (ER) and p53 expression was analyzed by immunohistochemistry (IHC) in a panel of 57 (36 ER-, 21 ER+) breast tumors. Representative images from IHC and hematoxylin and eosin (HE) staining of ER-/p53+ (row 1), ER-/p53- (row 2), ER+/p53- (rows 3 and 4) and ER+/p53+ (row 5) breast tumors. Original magnification: 20 ×. (C) TrxR1 (IHC) scoring in ER- and ER+ tumors. (D) TrxR1 (IHC) scoring in p53- and p53+ breast tumors. TrxR, thioredoxin reductase.Back to article page