A common copy-number breakpoint near the KRT40 gene. Heat maps were created from the tiling-path BAC array data by Staaf et al.  and are shown for a 3-Mb region (35 to 38 Mb in hg18) of chromosome 17. The locations of ERBB2 and KRT40 are shown. Top, heat maps of 200 ERBB2-amplified breast tumors, and bottom, heat maps of a subset (11) of tumors with copy-number breakpoints near KRT40. Red, copy-number increase; blue, copy-number loss.