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Table 5 Evaluation of acquisition parameters on the association between adjusteda dense area and non-dense area estimated from enrollment (screen-film) mammograms and risk of breast cancer in the Mayo Mammography Health Study cohort (2003 to 2009)

From: The influence of mammogram acquisition on the mammographic density and breast cancer association in the mayo mammography health study cohort

    

Models with addition of acquisition parameters

   

Models with no acquisition parameters

kVp - 3 levels

mAs

Thickness

Compression

All 4 acquisition parameters

Dense area, mm2

Number of cases

Person-years in subcohort

HRb (95% CI)

HRb (95% CI)

HRb (95% CI)

HRb (95% CI)

HRb (95% CI)

HRb (95% CI)

0 to 985

53

2,373.0

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

985.1 to 2,023

58

2,394.0

1.43 (0.97 2.10)

1.42 (0.96, 2.09)

1.42 (0.97, 2.09)

1.42 (0.97, 2.10)

1.42 (0.97, 2.09)

1.41 (0.96, 2.07)

2,023.1 to 3,237

63

2,367.9

1.70 (1.16, 2.50)

1.68 (1.14, 2.47)

1.68 (1.14, 2.48)

1.70 (1.16, 2.50)

1.72 (1.17, 2.53)

1.68 (1.14, 2.49)

3,237.1+

80

2,454.1

2.15 (1.49, 3.12)

2.10 (1.43, 3.07)

2.11 (1.45, 3.08)

2.15 (1.49, 3.12)

2.17 (1.49, 3.14)

2.07 (1.40, 3.08)

mAs

  

-

1.06 (0.88, 1.27)

   

1.05 (0.86, 1.29)

kVp

    

1.05 (0.90, 1.22)

  

1.06 (0.85, 1.33)

mm

     

1.05 (0.90, 1.23)

 

0.97 (0.77, 1.23)

Pounds

      

0.91 (0.80 1.04)

0.91 (0.79, 1.04)

Non-dense area, mm2

        

0 to 985

58

2,397.1

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

985.1 to 2,023

69

2,436.5

0.90 (0.62, 1.30)

0.89 (0.61, 1.28)

0.89 (0.61, 1.28)

0.88 (0.61, 1.28)

0.92 (0.63, 1.32)

0.94 (0.64, 1.37)

2,023.1 to 3,237

67

2,360.1

0.73 (0.49, 1.10)

0.74 (0.49, 1.11)

0.73 (0.48, 1.09)

0.72 (0.48, 1.08)

0.75 (0.50, 1.14)

0.80 (0.52, 1.22)

3,237.1+

60

2,395.4

0.53 (0.33, 0.86)

0.54 (0.33, 0.87)

0.53 (0.33, 0.86)

0.53 (0.33, 0.85)

0.55 (0.34, 0.90)

0.58 (0.36, 0.95)

mAs

  

-

1.13 (0.95, 1.36)

   

1.13 (0.93, 1.38)

kVp

    

1.10 (0.95, 1.28)

  

1.16 (0.94, 1.44)

mm

     

1.05 (0.90, 1.23)

 

0.88 (0.70, 1.11)

Pounds

      

0.95 (0.83, 1.08)

0.92 (0.81, 1.06)

  1. aAnalyses adjusted for age, menopausal status, post-menopausal hormone use, and body mass index. bHazard ratios (HRs) corresponding to milliampere-seconds (mAs), thickness, and compression refer to a 1 standard deviation (SD) change in the respective parameter (SD: mAs = 49.5, thickness = 12.7, compression = 5.6). HRs corresponding to voltage peak (kVp) are based on a tri-level ordinal variable (22-25, 26-27, 28-32). Owing to missing acquisition parameters, 18 cases and 47 controls that were included in the analyses depicted in Table 2 are not included here. CI, confidence interval; Ref., reference value.
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Breast Cancer Research

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