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Table 3 Mean case risk percentiles for BCRAT and IBIS among subgroups of subjects.

From: Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance

 

N

BCRAT

IBIS

Pvalueª

Age (yrs) at risk assignment

<35

7

18.8

31.2

0.2969

35-49

38

56.9

66.9

0.0377

50+

38

77.7

79.1

0.7489

Age (yrs) at first menarche

<14 yrs

67

63.6

69.7

0.0717

> = 14 or unknown

16

61.2

68.6

0.4637

Age (yrs) at FLB

<25 yrs

20

67.7

61.3

0.2268

> = 25 or nulliparous

63

61.8

72.1

0.0022

Menopausal status

Pre

43

51.8

61.9

0.0196

Post

40

75.4

77.6

0.6064

HRT use

Never

59

58.3

66.8

0.0149

Ever

24

75.1

76.1

0.9119

Number of breast biopsies

0

61

56.4

68.7

0.0001

1+

22

81.9

71.7

0.0118

BMI (kg/m²)

<25

48

62.5

65.6

0.9919

> = 25

35

64.1

74.8

0.0014

First-degree female relatives with BC

0

26

45.1

56.8

0.0967

1+

57

71.4

75.2

0.1816

Second/third-degree relatives with BC

0

37

67.4

70.7

0.7617

1+

46

59.8

68.5

0.0185

Relatives with OC

0

61

65.4

67.5

0.5412

1+

22

57.0

75.1

0.0094

BRCA mutation status

Test result positive

14

61.4

98.1

0.0001

Test result negative

37

68.8

65.5

0.1457

Untested

32

57.5

61.6

0.1823

Ethnicity

Non-Hispanic White

74

65.2

72.1

0.0638

Other

9

46.6

48.1

0.4961

  1. ªUsing Wilcoxon signed rank test. BC, breast cancer; FLB, first live birth; HRT, hormone replacement therapy; OC, ovarian cancer.