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Table 1 Patient characteristics by analysis cohort

From: Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX

 

Trial VIII

Trial IX

Pooled Trials

p53

Analyzed

Not analyzed

Analyzed

Not analyzed

Analyzed

Not analyzed

Number of patients

417

646

696

973

1,113

1,619

Median age (range)

46

45

61

60

  
 

(26 to 58)

(22 to 56)

(42 to 77)

(34 to 81)

  
  

ns

 

ns

  

ER status, n

      

Absent

84

101

128

137

212

238

> = 1%

322

360

558

516

880

876

Missing

11

185

10

320

21

505

  

ns1

 

ns

  

Tumor size, n

      

0 to 1 cm

27

99

65

136

92

235

> 1 to 2 cm

206

321

333

450

539

771

> 2 cm

182

217

280

352

462

569

Missing

2

9

18

35

20

44

  

P < 0.0001

 

P = 0.01

  

Tumor grade, n

      
 

52

94

85

160

137

254

1

171

286

304

447

475

733

2

168

179

248

261

416

440

3

26

87

59

105

85

192

Missing

 

P = 0.002

 

P = 0.0004

  

10-year DFS

71.3%

76.0%

P = 0.152

67.6%

75.5%

P = 0.10

  

10-year OS

86.4%

87.4%

P = 0.44

81.1%

83.8%

P = 0.65

  
  1. 1P-values compare distribution of non-missing values between analyzed and non-analyzed cohorts; ns, not significant. 2DFS and OS P-values based on logrank comparison of entire curves. n, number of patients; DFS, disease-free survival; OS, overall survival.
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Breast Cancer Research

ISSN: 1465-542X

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