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Table 5 Performance of Manchester Scoring method before and after adjustment with ER status or ER and PTEN status

From: Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

Manchester Scoring method

Cohort, n

Total BRCA1 carriers, n

No pathology adjustment

With pathology adjustment

   

Individuals tested, n

BRCA1carriers tested, n

Individuals tested, n

BRCA1carriers tested, n

Adjustment + estrogen-receptor status

345

28

72

12

82

18

Adjustment + estrogen-receptor + PTEN status

26

7

5

3

10

6

  1. The predicted and observed numbers of BRCA1 and BRCA2 (combined) carriers in women with low (1 to 14) and high Manchester score, either without adjustment for pathologic features, or with adjustment for ER status and other features [17–19], or further adjustment including +1 for loss of PTEN.