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Table 5 Performance of Manchester Scoring method before and after adjustment with ER status or ER and PTEN status

From: Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

Manchester Scoring method Cohort, n Total BRCA1 carriers, n No pathology adjustment With pathology adjustment
    Individuals tested, n BRCA1carriers tested, n Individuals tested, n BRCA1carriers tested, n
Adjustment + estrogen-receptor status 345 28 72 12 82 18
Adjustment + estrogen-receptor + PTEN status 26 7 5 3 10 6
  1. The predicted and observed numbers of BRCA1 and BRCA2 (combined) carriers in women with low (1 to 14) and high Manchester score, either without adjustment for pathologic features, or with adjustment for ER status and other features [1719], or further adjustment including +1 for loss of PTEN.