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Table 2 Hormone change during weight loss and maintenance among postmenopausal women not taking hormones

From: Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women

  Months since study entry Effect of weight on hormones
  Study entry End of weight loss phase Weight loss maintenance Weight loss, entry vs. 6 months Weight maintenance, 6 months vs. 18 months
  Initial 6 months 18 months % Δ P value % Δ P value
Weight (kg)a 89.1 (14.8) 81.4 (14.4) 83.6 (15.6) -7.7 <0.0001 2.2 <0.0001
Hormone        
   Estrone (pg/ml) 38.1 (1.1) 35.9 (1.0) 33.6 (1.0) -5.7 0.006 -6.4 0.003
   Estradiol (pg/ml) 9.4 (0.3) 8.4 (0.3) 8.5 (0.3) -9.9 <0.0001 0.5 0.85
   Testosterone (ng/ml) 24.6 (0.9) 23.7 (0.8) 24.0 (0.8) -3.5 0.13 1.1 0.62
   Androstenedione (pg/ml) 437 (12.1) 434 (11.9) 438 (12.9) -0.5 0.76 0.8 0.68
   Dehydroepiandrosterone sulfate (µg/dl) 47.0 (1.8) 47.8 (1.8) 46.6 (1.9) 1.7 0.31 -2.5 0.18
   Sex hormone binding globulin (nmol/l) 35 (1.0) 40 (1.0) 37 (1.0) 16.2 <0.0001 -8.0 <0.0001
   Free estradiol (pg/ml) 0.26 (0.01) 0.22 (0.01) 0.23 (0.01) -13.4 <0.0001 3.7 0.18
   Free testosterone (pg/ml) 5.3 (0.2) 4.8 (0.2) 5.1 (0.2) -9.9 <0.0001 5.0 0.02
  1. n = 278. Generalized estimating equations models used to estimate the mean (standard error) and percentage change (% Δ) in hormone concentrations over each study phase adjusted for age, physical activity, phase, initial body mass index (kg/m2), and race. aRow represents the mean (standard deviation) for weight at the start of each phase, average weight change between each phase and overall.
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