| |
Months since study entry
|
Effect of weight on hormones
|
|---|
| |
Study entry
|
End of weight loss phase
|
Weight loss maintenance
|
Weight loss, entry vs. 6 months
|
Weight maintenance, 6 months vs. 18 months
|
|---|
| |
Initial
|
6 months
|
18 months
|
% Δ
|
P value
|
% Δ
|
P value
|
|---|
|
Weight (kg)a
|
89.1 (14.8)
|
81.4 (14.4)
|
83.6 (15.6)
|
-7.7
|
<0.0001
|
2.2
|
<0.0001
|
|
Hormone
| | | | | | | |
|
Estrone (pg/ml)
|
38.1 (1.1)
|
35.9 (1.0)
|
33.6 (1.0)
|
-5.7
|
0.006
|
-6.4
|
0.003
|
|
Estradiol (pg/ml)
|
9.4 (0.3)
|
8.4 (0.3)
|
8.5 (0.3)
|
-9.9
|
<0.0001
|
0.5
|
0.85
|
|
Testosterone (ng/ml)
|
24.6 (0.9)
|
23.7 (0.8)
|
24.0 (0.8)
|
-3.5
|
0.13
|
1.1
|
0.62
|
|
Androstenedione (pg/ml)
|
437 (12.1)
|
434 (11.9)
|
438 (12.9)
|
-0.5
|
0.76
|
0.8
|
0.68
|
|
Dehydroepiandrosterone sulfate (µg/dl)
|
47.0 (1.8)
|
47.8 (1.8)
|
46.6 (1.9)
|
1.7
|
0.31
|
-2.5
|
0.18
|
|
Sex hormone binding globulin (nmol/l)
|
35 (1.0)
|
40 (1.0)
|
37 (1.0)
|
16.2
|
<0.0001
|
-8.0
|
<0.0001
|
|
Free estradiol (pg/ml)
|
0.26 (0.01)
|
0.22 (0.01)
|
0.23 (0.01)
|
-13.4
|
<0.0001
|
3.7
|
0.18
|
|
Free testosterone (pg/ml)
|
5.3 (0.2)
|
4.8 (0.2)
|
5.1 (0.2)
|
-9.9
|
<0.0001
|
5.0
|
0.02
|
- n = 278. Generalized estimating equations models used to estimate the mean (standard error) and percentage change (% Δ) in hormone concentrations over each study phase adjusted for age, physical activity, phase, initial body mass index (kg/m2), and race. aRow represents the mean (standard deviation) for weight at the start of each phase, average weight change between each phase and overall.
