| Months since study entry | Effect of weight on hormones | |||||
---|---|---|---|---|---|---|---|
 | Study entry | End of weight loss phase | Weight loss maintenance | Weight loss, entry vs. 6 months | Weight maintenance, 6 months vs. 18 months | ||
 | Initial | 6 months | 18 months | % Δ | P value | % Δ | P value |
Weight (kg)a | 89.1 (14.8) | 81.4 (14.4) | 83.6 (15.6) | -7.7 | <0.0001 | 2.2 | <0.0001 |
Hormone | Â | Â | Â | Â | Â | Â | Â |
   Estrone (pg/ml) | 38.1 (1.1) | 35.9 (1.0) | 33.6 (1.0) | -5.7 | 0.006 | -6.4 | 0.003 |
   Estradiol (pg/ml) | 9.4 (0.3) | 8.4 (0.3) | 8.5 (0.3) | -9.9 | <0.0001 | 0.5 | 0.85 |
   Testosterone (ng/ml) | 24.6 (0.9) | 23.7 (0.8) | 24.0 (0.8) | -3.5 | 0.13 | 1.1 | 0.62 |
   Androstenedione (pg/ml) | 437 (12.1) | 434 (11.9) | 438 (12.9) | -0.5 | 0.76 | 0.8 | 0.68 |
   Dehydroepiandrosterone sulfate (µg/dl) | 47.0 (1.8) | 47.8 (1.8) | 46.6 (1.9) | 1.7 | 0.31 | -2.5 | 0.18 |
   Sex hormone binding globulin (nmol/l) | 35 (1.0) | 40 (1.0) | 37 (1.0) | 16.2 | <0.0001 | -8.0 | <0.0001 |
   Free estradiol (pg/ml) | 0.26 (0.01) | 0.22 (0.01) | 0.23 (0.01) | -13.4 | <0.0001 | 3.7 | 0.18 |
   Free testosterone (pg/ml) | 5.3 (0.2) | 4.8 (0.2) | 5.1 (0.2) | -9.9 | <0.0001 | 5.0 | 0.02 |