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Table 3 Univariate and multivariate analysis for overall survival

From: Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer

  Univariate analysis Multivariate analysis
Factors RR 95% CI P RR 95% CI P
Lymphnode metastasis (negative/positive) 2.91 1.86 to 5.03 <0.0001 2.67 1.53 to 4.96 <0.001
Hormone receptor (positive/negative) 2.37 1.61 to 3.59 <0.0001 2.65 1.62 to 4.43 0.0001
VEGFR-1 mRNA expression (negative/positive) 1.86 1.19 to 2.79 <0.01 2.00 1.19 to 3.25 <0.01
CEA (<5.0 ng/ml/ >5.1 ng/ml) 2.23 1.20 to 3.65 <0.05 1.69 0.87 to 2.95 0.11
Tumor size (small/large) 2.14 1.26 to 4.39 <0.01 1.63 0.85 to 4.13 0.16
Nuclear grade (I and II/III) 1.62 1.11 to 2.39 <0.05 1.25 0.82 to 1.89 0.29
Lymphatic involvement (negative/positive) 1.51 1.03 to 2.26 <0.05 0.99 0.62 to 1.61 0.96
Vascular involvement (negative/positive) 1.85 1.00 to 3.01 0.05 - - -
HER-2/NEU (negative/positive) 1.48 0.96 to 2.26 0.08 - - -
  1. CI, Confidence interval; RR, Relative risk
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