Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer

Table 2 Correlation of clinicopathologic characterestics and VEGFR1 mRNA expression

	VEGFR1mRNA in peripheral blood
	negative		Positive
	(n = 466)		(n = 49)
Factors	No.	%	No.	%	P
Age (mean ± SD)	55.5 ± 11.5		54.5 ± 11.5		0.66
Tumor size
small (Tis to T1)	189	40.6	13	26.5	<0.05
large (T2 to T4)	277	59.4	36	73.5
Lymphnode metastasis
negative	316	67.8	26	53.1	<0.05
positive	150	32.2	23	46.9
Lymphatic involvement
negative	289	62.0	27	55.1	0.34
positive	177	38.0	22	44.9
Vascular involvement
negative	438	94.0	43	87.8	0.09
positive	28	6.0	6	12.2
Nuclear grade
I/II	311	66.7	35	71.4	0.50
III	155	33.3	14	28.6
Hormone receptor
negative	112	24.0	11	22.4	0.80
positive	354	76.0	38	77.6
HER-2/NEU
negative	301	86.0	18	94.7	0.23
positive	49	14.0	1	5.3
CEA
<5.0	408	94.9	44	95.7	0.82
>5.1	22	5.1	2	4.3
Stage
0	6	1.3	0	0.0	<0.01
I	143	30.7	12	24.5
II	290	62.2	26	53.1
III	27	5.8	11	22.4
Recurrence
negative	404	86.7	34	69.4	<0.01
positive	62	13.3	15	30.6
Prognosis
alive	449	96.4	39	79.6	<0.0001
dead	17	3.6	10	20.4

ISSN: 1465-542X