|
Recurrence-free survival
|
|---|
|
Variable
|
HR
|
95% CI
|
Pvalue
|
FDR
|
|---|
|
Translational regulator
| | | | |
|
p4E-BP1 S65
|
1.51
|
1.08-2.11
|
0.02
|
0.09
|
|
p4E-BP1 T36/47
|
1.49
|
1.05-2.12
|
0.03
|
0.09
|
|
4E-BP1
|
1.66
|
1.04-2.65
|
0.04
|
0.09
|
|
p4E-BP1 T70
|
1.38
|
1.00-1.90
|
0.05
|
0.10
|
|
pS6 S235/236
|
1.37
|
0.81-2.31
|
0.23
|
0.27
|
|
pS6 S240/244
|
1.23
|
0.83-1.83
|
0.30
|
0.29
|
|
eIF4G
|
1.33
|
0.77-2.30
|
0.30
|
0.30
|
|
Pdcd4
|
0.81
|
0.52-1.26
|
0.34
|
0.31
|
|
eIF4E
|
1.12
|
0.75-1.67
|
0.58
|
0.43
|
|
S6
|
0.96
|
0.67-1.37
|
0.82
|
0.52
|
|
eEF2K
|
1.04
|
0.70-1.55
|
0.83
|
0.52
|
|
eEF2
|
0.98
|
0.59-1.61
|
0.93
|
0.55
|
|
Age at diagnosis
|
1.01
|
0.98-1.04
|
0.64
| |
|
Nodal Status
| | | | |
|
Negative
|
1
| | | |
|
Positive
|
2.789
|
1.55-5.03
|
<0.01
| |
|
T Stage
| | | | |
|
T1
|
1
| | | |
|
T2-4
|
1.339
|
0.71-2.52
|
0.37
| |
|
Overall survival
|
|
Variable
|
HR
|
95% CI
| |
FDR
|
|
Translational regulator
| | | | |
|
Pdcd4
|
0.62
|
0.42-0.91
|
0.0155
|
0.06
|
|
p4E-BP1 T70
|
1.30
|
0.98-1.71
|
0.0662
|
0.12
|
|
pS6 S235/236
|
1.40
|
0.90-2.18
|
0.1369
|
0.14
|
|
eEF2
|
1.27
|
0.82-1.95
|
0.2852
|
0.15
|
|
4EBP1
|
1.22
|
0.78-1.91
|
0.3801
|
0.16
|
|
eEF2K
|
1.15
|
0.82-1.62
|
0.4093
|
0.16
|
|
p4E-BP1 S65
|
1.15
|
0.82-1.60
|
0.4144
|
0.16
|
|
S6
|
1.14
|
0.83-1.55
|
0.4192
|
0.16
|
|
pS6 S240/244
|
1.14
|
0.81-1.60
|
0.4484
|
0.16
|
|
p4E-BP1 T36/47
|
1.13
|
0.81-1.56
|
0.4670
|
0.16
|
|
eIF4E
|
0.94
|
0.68-1.31
|
0.7162
|
0.22
|
|
eIF4G
|
0.98
|
0.61-1.55
|
0.9142
|
0.27
|
|
Age at diagnosis
|
1.05
|
1.03-1.08
|
<0.01
| |
|
Nodal status
| | | | |
|
Negative
|
1
| | | |
|
Positive
|
2.05
|
1.25-3.35
|
<0.01
| |
|
T Stage
| | | | |
|
T1
|
1
| | | |
|
T2-T4
|
1.36
|
0.79-2.34
|
0.26
| |
- CI, confidence interval; FDR, false discovery rate; HR, hazard ratio.
