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Table 2 Univariate analysis of RFS and OS for hormone receptor-positive breast cancer patients.

From: Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

Recurrence-free survival
Variable HR 95% CI Pvalue FDR
Translational regulator     
   p4E-BP1 S65 1.51 1.08-2.11 0.02 0.09
   p4E-BP1 T36/47 1.49 1.05-2.12 0.03 0.09
   4E-BP1 1.66 1.04-2.65 0.04 0.09
   p4E-BP1 T70 1.38 1.00-1.90 0.05 0.10
   pS6 S235/236 1.37 0.81-2.31 0.23 0.27
   pS6 S240/244 1.23 0.83-1.83 0.30 0.29
   eIF4G 1.33 0.77-2.30 0.30 0.30
   Pdcd4 0.81 0.52-1.26 0.34 0.31
   eIF4E 1.12 0.75-1.67 0.58 0.43
   S6 0.96 0.67-1.37 0.82 0.52
   eEF2K 1.04 0.70-1.55 0.83 0.52
   eEF2 0.98 0.59-1.61 0.93 0.55
Age at diagnosis 1.01 0.98-1.04 0.64  
Nodal Status     
   Negative 1    
   Positive 2.789 1.55-5.03 <0.01  
T Stage     
   T1 1    
   T2-4 1.339 0.71-2.52 0.37  
Overall survival
Variable HR 95% CI   FDR
Translational regulator     
   Pdcd4 0.62 0.42-0.91 0.0155 0.06
   p4E-BP1 T70 1.30 0.98-1.71 0.0662 0.12
   pS6 S235/236 1.40 0.90-2.18 0.1369 0.14
   eEF2 1.27 0.82-1.95 0.2852 0.15
   4EBP1 1.22 0.78-1.91 0.3801 0.16
   eEF2K 1.15 0.82-1.62 0.4093 0.16
   p4E-BP1 S65 1.15 0.82-1.60 0.4144 0.16
   S6 1.14 0.83-1.55 0.4192 0.16
   pS6 S240/244 1.14 0.81-1.60 0.4484 0.16
   p4E-BP1 T36/47 1.13 0.81-1.56 0.4670 0.16
   eIF4E 0.94 0.68-1.31 0.7162 0.22
   eIF4G 0.98 0.61-1.55 0.9142 0.27
Age at diagnosis 1.05 1.03-1.08 <0.01  
Nodal status     
   Negative 1    
   Positive 2.05 1.25-3.35 <0.01  
T Stage     
   T1 1    
   T2-T4 1.36 0.79-2.34 0.26  
  1. CI, confidence interval; FDR, false discovery rate; HR, hazard ratio.
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