Figure 5

Schematic model illustrating the role of p130Cas in sustaining the mesenchymal features of breast cancer cells. p130Cas supports mesenchymal traits of breast cancer cells by sustaining Src, JNK activities (see stars), and expression of Cyclooxygenase-2 (Cox-2), leading to tumor growth. In contrast, low levels of p130Cas, preventing the activation of downstream signaling pathways, allow cells to acquire epithelial features, impairing tumor growth.