QSOX1 reduces breast cancer xenograft formation. 2.106 MDA-MB-231 shC and MDA-MB-231 shQSOX1-1 cells were injected subcutaneously in CIEA NOG mice (n = 5 per group). Tumor volume was calculated by the formula V = ½ a × b2, where a is the longest tumor axis, and b is the shortest tumor axis. (A) 42 days after injection, tumors were fixed in formol and photographed, (B) 21 days after injection, the evolution of the tumor volume was measured biweekly. * P <0.05, compared to control (Wilcoxon test). This experiment is representative of two separate assays.