Figure 5From: Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretionModel of the HER2/HER3/IL8 signaling cascade. Heregulin-induced heterodimerization and activation of HER2/HER3 causes upregulation of the IL8 transcript, which in turn mediates invasion via CXCR1.Back to article page