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Table 2 Univariate and multivariate survival analyses of breast cancer-specific survival (CSS) in Materials III and IV

From: Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

Material III CSS (n = 218)   Multivariate adjusted (Weibull) Univariate unadjusted (Weibull)
Variable n Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Grade 1 57 1 - 1 -
  2 95 1.01 (0.45 to 2.26) 0.977 1.33 (0.62 to 2.85) 0.472
  3 66 1.59 (0.65 to 3.87) 0.306 1.90 (0.88 to 4.08) 0.102
Size < 2 cm 108 1 - 1 -
  2 to ≥ 5 cm 101 1.59 (0.82 to 3.08) 0.166 1.88 (1.03 to 3.45) 0.041
  > 5 cm 9 2.38 (0.74 to 7.60) 0.145 2.86 (0.94 to 8.76) 0.065
ER/PR status Neg 43 1 - 1 -
  Pos 175 1.49 (0.68 to 3.26) 0.321 0.87 (0.45 to 1.70) 0.688
Stat5a Low (0) 30 2.34 (1.16 to 4.71) 0.018 2.35 (1.20 to 4.58) 0.012
  High (> 0) 188 1 - 1 -
Global test for PH assumption: χ2 (4) = 17.18; P = 0.0018.
Material IV CSS ( n = 190)   Multivariate adjusted (Weibull) Univariate unadjusted (Weibull)
Variable n Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Grade 1 42 1 - 1 -
  2 110 1.55 (0.84 to 2.84) 0.162 1.42 (0.77 to 2.59) 0.258
  3 38 1.11 (0.50 to 2.47) 0.797 1.10 (0.52 to 2.35) 0.801
Size < 2 cm 71 1 - 1 -
  2 to ≥5 cm 98 2.10 (1.19 to 3.72) 0.011 2.01 (1.14 to 3.55) 0.016
  ≥5 cm 21 3.48 (1.61 to 7.54) 0.002 3.09 (1.45 to 6.58) 0.004
ER/PR status Neg 41 1 - 1 -
  Pos 149 0.93 (0.49 to 1.75) 0.824 0.91 (0.52 to 1.59) 0.738
Her2 status Neg 166 1 - 1 -
  Pos 24 1.02 (0.47 to 2.20) 0.963 0.97 (0.48 to 1.96) 0.939
Stat5a Low (< 881) 158 2.15 (1.02 to 4.55) 0.045 2.13 (1.01 to 4.49) 0.047
  High (≥881) 32 1 - 1 -
  1. Global test for PH assumption: χ2(5) = 10.05; P = 0.074.