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Table 2 Univariate and multivariate survival analyses of breast cancer-specific survival (CSS) in Materials III and IV

From: Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

Material III CSS (n = 218)

 

Multivariate adjusted (Weibull)

Univariate unadjusted (Weibull)

Variable

n

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Grade

1

57

1

-

1

-

 

2

95

1.01 (0.45 to 2.26)

0.977

1.33 (0.62 to 2.85)

0.472

 

3

66

1.59 (0.65 to 3.87)

0.306

1.90 (0.88 to 4.08)

0.102

Size

< 2 cm

108

1

-

1

-

 

2 to ≥ 5 cm

101

1.59 (0.82 to 3.08)

0.166

1.88 (1.03 to 3.45)

0.041

 

> 5 cm

9

2.38 (0.74 to 7.60)

0.145

2.86 (0.94 to 8.76)

0.065

ER/PR status

Neg

43

1

-

1

-

 

Pos

175

1.49 (0.68 to 3.26)

0.321

0.87 (0.45 to 1.70)

0.688

Stat5a

Low (0)

30

2.34 (1.16 to 4.71)

0.018

2.35 (1.20 to 4.58)

0.012

 

High (> 0)

188

1

-

1

-

Global test for PH assumption: χ2 (4) = 17.18; P = 0.0018.

Material IV CSS ( n = 190)

 

Multivariate adjusted (Weibull)

Univariate unadjusted (Weibull)

Variable

n

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Grade

1

42

1

-

1

-

 

2

110

1.55 (0.84 to 2.84)

0.162

1.42 (0.77 to 2.59)

0.258

 

3

38

1.11 (0.50 to 2.47)

0.797

1.10 (0.52 to 2.35)

0.801

Size

< 2 cm

71

1

-

1

-

 

2 to ≥5 cm

98

2.10 (1.19 to 3.72)

0.011

2.01 (1.14 to 3.55)

0.016

 

≥5 cm

21

3.48 (1.61 to 7.54)

0.002

3.09 (1.45 to 6.58)

0.004

ER/PR status

Neg

41

1

-

1

-

 

Pos

149

0.93 (0.49 to 1.75)

0.824

0.91 (0.52 to 1.59)

0.738

Her2 status

Neg

166

1

-

1

-

 

Pos

24

1.02 (0.47 to 2.20)

0.963

0.97 (0.48 to 1.96)

0.939

Stat5a

Low (< 881)

158

2.15 (1.02 to 4.55)

0.045

2.13 (1.01 to 4.49)

0.047

 

High (≥881)

32

1

-

1

-

  1. Global test for PH assumption: χ2(5) = 10.05; P = 0.074.