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Figure 7 | Breast Cancer Research

Figure 7

From: NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro

Figure 7

NOTCH1 inhibition reduces mammary tumorsphere formation. (A) Quantification of tumorsphere-forming potential of primary tumor cells isolated from dissociated MMTV-tTA/TOP-ICN1 tumors left untreated or treated with doxycycline (2 μg/ml) for 8 days. Error bars denote standard error (n = 3). (B) Representative images of untreated and doxycycline-treated mammary tumorspheres showing relative difference in tumorsphere size and morphology. Examples of spheres that were counted are indicated with arrows.

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