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Table 1 Immunogenic peptides derived from HER2/neu protein that are naturally processed and presented

From: Update on HER-2 as a target for cancer therapy: HER2/neu peptides as tumour vaccines for T cell recognition

MHC

Peptide

Sequence

Reference

HLA-A*0201

HER2 5–13

ALCRWGLLL

[19]

 

HER2 106–114

QLFEDNYAL

[20]

 

HER2 369–377

KIFGSLAFL

[7,19,20,21]

 

HER2 435–443

ILHNGAYSL

[19,22]

 

HER2 654–662

IISAVVGIL

[23]

 

HER2 665–673

VVLGVVFGI

[22]

 

HER2 689–697

RLLQETELV

[20]

 

HER2 773–782

VMAGVGSPYV

[21]

 

HER2 789–797

CLTSTVQLV

[7]

 

HER2 799–807

QLMPYGCLL

[7]

 

HER2 835–842

YLEDVRLV

[7]

 

HER2 851–859

VLVKSPNHV

[7]

 

HER2 952–961

YMIMVKCWMI

[22]

 

HER2 971–979

ELVSEFSRM

[7]

HLA-A*0301

HER2 754–762

VLRENTSPK

[24]

HLA-A*2402

HER2 8–16

RWGLLLALL

[25]

 

HER2 63–71

TYLPTNASL

[26]

 

HER2 780–788

PYVSRLLGI

[27]

HLA-DR1, DR4, DR52, DR53

HER2 883–899

KVPIKWMALESILRRRF

[8]

  1. MHC, Major histocompatibility complex. Also binds to three other alleles of the HLA-A3 superfamily: A*1101, A*3101 and A*3301.