Features of the ERBB2 promoter. The ERBB2 promoter from -75 to +15 is represented approximately to scale, with an additional area depicting sequences upstream of -200. The major (+1) and minor (-69) transcription start sites are indicated with arrows and the positions of the TATA and CCAAT boxes are marked; the polypyrimidine/polypurine repeat is shown as an open box. The relative positions of the main transcription factor binding sites AP-2, Ets and ZONAB are indicated, with the sequences below each giving the core binding site defined for each factor. Translation of the protein begins at +178 relative to the major transcription start site.