Figure 1
From: Intracellular signaling pathways of ErbB2/HER-2 and family members
ErbB receptors and their cytoplasmic partners. The interaction of various proteins containing Src homology 2 and phosphotyrosine binding domains has been mapped to specific ErbB carboxy-terminal tyrosines. Autophosphorylation sites are shown in red, interaction sites demonstrated by phosphopeptide competition analyses are in black, and sites identified as Src phosphorylation sites are in blue. The receptor-associated late transducer (Ralt) and the PDZ proteins PSD-95, Erbin and Pick1 interact with the receptors in a phosphorylation-independent manner.