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Table 4 SIRs for mothers and sisters by morphology features of the subgroup of 375 index cases.

From: Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry

Feature   Observed Expeceted SIR (95% CI) Ratio of SIRs (95% CI) P
Number of mitoses >50 Absent 60 28.50 2.11 (1.64 to 2.71) 1.91 (0.83 to 3.87) 0.07
  Present 9 2.24 4.02 (2.09 to 7.73)    
Nuclear grade - malignant Absent 10 4.67 2.14 (1.15 to 3.98) 1.06 (0.54 to 2.32) 0.9
  Present 59 26.06 2.26 (1.75 to 2.92)    
Tubule formation <10 Absent 16 7.86 2.04 (1.25 to 3.32) 1.14 (0.64 to 2.13) 0.7
  Present 53 22.87 2.32 (1.77 to 3.03)    
Syncytial pattern ≥75% Absent 64 29.42 2.18 (1.70 to 2.78) 1.75 (0.55 to 4.31) 0.2
  Present 5 1.31 3.81 (1.58 to 9.14)    
Circumscribed Absent 51 26.29 1.94 (1.47 to 2.55) 2.09 (1.15 to 3.63) 0.01
  Present 18 4.45 4.04 (2.55 to 6.42)    
Pushing margins Absent 66 29.98 2.10 (1.64 to 2.69) 3.76 (1.33 to 8.64) 0.002
  Present 6 0.76 7.90 (3.55 to 17.59)    
Lymphocytic infiltrate I - diffuse Absent 38 19.42 1.96 (1.42 to 2.69) 1.40 (0.84 to 2.31) 0.2
  Present 31 11.32 2.74 (1.93 to 3.89)    
Lymphocytic infiltrate II-intense Absent 53 25.89 2.05 (1.56 to 2.68) 1.61 (0.86 to 2.86) 0.1
  Present 16 4.85 3.30 (2.02 to 5.39)    
Glandular growth pattern Absent 25 7.58 3.30 (2.23 to 4.88) 0.58 (0.34 to 0.98) 0.03
  Present 44 23.16 1.90 (1.41 to 2.55)    
Lobular growth pattern Absent 36 18.34 1.96 (1.42 to 2.72) 1.36 (0.82 to 2.24) 0.2
  Present 33 12.40 2.66 (1.89 to 3.74)    
Trabecular growth pattern Absent 54 25.90 2.09 (1.60 to 2.72) 1.49 (0.78 to 2.67) 0.2
  Present 15 4.84 3.10 (1.87 to 5.15)    
Tubular growth pattern Absent 59 25.25 2.34 (1.81 to 3.02) 0.78 (0.36 to 1.54) 0.5
  Present 10 5.49 1.82 (0.98 to 3.39)    
Acinar growth pattern Absent 62 26.10 2.37 (1.85 to 3.04) 0.65 (0.25 to 1.42) 0.3
  Present 7 4.56 1.54 (0.73 to 3.22)    
Sclerosis - extensive Absent 8 1.45 5.52 (2.76 to 11.04) 0.38 (0.18 to 0.91) 0.01
  Present 61 29.29 2.08 (1.62 to 2.68)    
Extensive intraductal carcinoma Absent 51 25.61 1.99 (1.51 to 2.62) 1.77 (0.97 to 3.06) 0.04
  Present 18 5.12 3.51 (2.21 to 5.58)    
Necrosis Absent 48 21.35 2.25 (1.70 to 2.98) 0.99 (0.57 to 1.69) 1.0
  Present 21 9.39 2.24 (1.46 to 3.43)    
Apoptosis - moderate or intense Absent 12 6.64 1.81 (1.03 to 3.18) 1.31 (0.69 to 2.68) 0.4
  Present 57 24.10 2.37 (1.83 to 3.07)    
Lymphatic invasion Absent 53 21.10 2.51 (1.92 to 3.29) 0.76 (0.35 to 1.17) 0.1
  Present 16 9.64 1.66 (1.02 to 2.71)    
ER positive Absent 25 10.00 2.50 (1.69 to 3.70) 0.65 (0.44 to 1.33) 0.3
  Present 34 17.85 1.91 (1.36 to 2.67)    
PR positive Absent 26 9.10 2.86 (1.95 to 4.20) 0.70 (0.38 to 1.13) 0.1
  Present 35 18.78 1.86 (1.34 to 2.60)