Table 2 SIRs for mothers and sisters by tumour morphology features of the 452 index cases: the Australian Breast Cancer Family Registry.

Number of mitoses >50

Absent

81

31.70

2.56

(2.06 to 3.18)

2.01

(1.23 to 3.19)

0.002

Present

25

4.86

5.14

(3.47 to 7.61)

Nuclear grade - malignant

Absent

13

5.32

2.44

(1.42 to 4.21)

1.22

(0.68 to 2.37)

0.5

Present

93

31.24

2.98

(2.43 to 3.65)

Tubule formation <10

Absent

21

9.18

2.29

(1.49 to 3.51)

1.36

(0.83 to 2.30)

0.2

Present

85

27.38

3.10

(2.51 to 3.84)

Syncytial pattern ≥75%

Absent

92

34.20

2.69

(2.19 to 3.30)

2.21

(1.16 to 3.89)

0.01

Present

14

2.36

5.93

(3.51 to 10.01)

Circumscribed

Absent

70

29.51

2.37

(1.88 to 3.00)

2.15

(1.40 to 3.26)

<0.001

Present

36

7.05

5.11

(3.68 to 7.08)

Pushing margins

Absent

96

35.40

2.71

(2.22 to 3.31)

3.15

(1.46 to 6.05)

0.001

Present

10

1.17

8.58

(4.62 to 15.95)

Lymphocytic infiltrate I - diffuse

Absent

58

23.20

2.50

(1.93 to 3.23)

1.44

(0.96 to 2.14)

0.06

Present

48

13.36

3.59

(2.71 to 4.77)

Lymphocytic infiltrate II-intense

Absent

73

29.83

2.45

(1.95 to 3.08)

2.00

(1.29 to 3.06)

0.001

Present

33

6.73

4.90

(3.49 to 6.90)

Glandular growth pattern

Absent

47

10.80

4.35

(3.27 to 5.79)

0.53

(0.35 to 0.79)

0.001

Present

59

25.76

2.29

(1.77 to 2.96)

Lobular growth pattern

Absent

62

22.80

2.72

(2.12 to 4.89)

1.18

(0.78 to 1.76)

0.4

Present

44

13.76

3.20

(2.38 to 4.30)

Trabecular growth pattern

Absent

70

28.65

2.44

(1.93 to 3.09)

1.86

(1.21 to 2.82)

0.002

Present

36

7.91

4.55

(3.28 to 6.31)

Tubular growth pattern

Absent

91

30.34

3.00

(2.44 to 3.68)

0.80

(0.43 to 1.39)

0.4

Present

15

6.23

2.41

(1.45 to 4.00)

Acinar growth pattern

Absent

90

30.03

3.00

(2.44 to 3.68)

0.82

(0.45 to 1.40)

0.5

Present

16

6.53

2.45

(1.51 to 4.00)

Sclerosis - extensive

Absent

20

2.36

8.46

(5.46 to 13.11)

0.30

(0.18 to 0.51)

<0.001

Present

86

34.20

2.52

(2.04 to 3.11)

Extensive intraductal carcinoma

Absent

81

30.74

2.34

(2.12 to 3.28)

1.63

(1.00 to 2.58)

0.03

Present

25

5.82

4.30

(2.90 to 6.36)

Necrosis

Absent

64

23.93

2.67

(2.09 to 3.42)

1.24

(0.82 to 1.86)

0.3

Present

42

13.63

3.33

(2.46 to 4.50)

Apoptosis - moderate or intense

Absent

16

7.30

2.19

(1.34 to 3.58)

1.40

(0.82 to 1.86)

0.2

Present

90

29.26

3.08

(2.50 to 3.78)

Lymphatic invasion

Absent

75

24.96

3.01

(2.40 to 3.77)

0.89

(0.57 to 1.37)

0.6

Present

31

11.60

2.67

(1.88 to 3.80)

ER positive

Absent

48

13.16

3.65

(2.75 to 4.84)

0.63

(0.41 to 0.96)

0.02

Present

46

20.16

2.28

(1.71 to 3.05)

PR positive

Absent

42

11.32

3.71

(2.75 to 5.02)

0.66

(0.43 to 1.01)

0.04

Present

54

22.03

2.45

(1.88 to 3.20)