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Table 2 SIRs for mothers and sisters by tumour morphology features of the 452 index cases: the Australian Breast Cancer Family Registry.

From: Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry

Feature   Observed Expeceted SIR (95% CI) Ratio of SIRs (95% CI) P
Number of mitoses >50 Absent 81 31.70 2.56 (2.06 to 3.18) 2.01 (1.23 to 3.19) 0.002
  Present 25 4.86 5.14 (3.47 to 7.61)    
Nuclear grade - malignant Absent 13 5.32 2.44 (1.42 to 4.21) 1.22 (0.68 to 2.37) 0.5
  Present 93 31.24 2.98 (2.43 to 3.65)    
Tubule formation <10 Absent 21 9.18 2.29 (1.49 to 3.51) 1.36 (0.83 to 2.30) 0.2
  Present 85 27.38 3.10 (2.51 to 3.84)    
Syncytial pattern ≥75% Absent 92 34.20 2.69 (2.19 to 3.30) 2.21 (1.16 to 3.89) 0.01
  Present 14 2.36 5.93 (3.51 to 10.01)    
Circumscribed Absent 70 29.51 2.37 (1.88 to 3.00) 2.15 (1.40 to 3.26) <0.001
  Present 36 7.05 5.11 (3.68 to 7.08)    
Pushing margins Absent 96 35.40 2.71 (2.22 to 3.31) 3.15 (1.46 to 6.05) 0.001
  Present 10 1.17 8.58 (4.62 to 15.95)    
Lymphocytic infiltrate I - diffuse Absent 58 23.20 2.50 (1.93 to 3.23) 1.44 (0.96 to 2.14) 0.06
  Present 48 13.36 3.59 (2.71 to 4.77)    
Lymphocytic infiltrate II-intense Absent 73 29.83 2.45 (1.95 to 3.08) 2.00 (1.29 to 3.06) 0.001
  Present 33 6.73 4.90 (3.49 to 6.90)    
Glandular growth pattern Absent 47 10.80 4.35 (3.27 to 5.79) 0.53 (0.35 to 0.79) 0.001
  Present 59 25.76 2.29 (1.77 to 2.96)    
Lobular growth pattern Absent 62 22.80 2.72 (2.12 to 4.89) 1.18 (0.78 to 1.76) 0.4
  Present 44 13.76 3.20 (2.38 to 4.30)    
Trabecular growth pattern Absent 70 28.65 2.44 (1.93 to 3.09) 1.86 (1.21 to 2.82) 0.002
  Present 36 7.91 4.55 (3.28 to 6.31)    
Tubular growth pattern Absent 91 30.34 3.00 (2.44 to 3.68) 0.80 (0.43 to 1.39) 0.4
  Present 15 6.23 2.41 (1.45 to 4.00)    
Acinar growth pattern Absent 90 30.03 3.00 (2.44 to 3.68) 0.82 (0.45 to 1.40) 0.5
  Present 16 6.53 2.45 (1.51 to 4.00)    
Sclerosis - extensive Absent 20 2.36 8.46 (5.46 to 13.11) 0.30 (0.18 to 0.51) <0.001
  Present 86 34.20 2.52 (2.04 to 3.11)    
Extensive intraductal carcinoma Absent 81 30.74 2.34 (2.12 to 3.28) 1.63 (1.00 to 2.58) 0.03
  Present 25 5.82 4.30 (2.90 to 6.36)    
Necrosis Absent 64 23.93 2.67 (2.09 to 3.42) 1.24 (0.82 to 1.86) 0.3
  Present 42 13.63 3.33 (2.46 to 4.50)    
Apoptosis - moderate or intense Absent 16 7.30 2.19 (1.34 to 3.58) 1.40 (0.82 to 1.86) 0.2
  Present 90 29.26 3.08 (2.50 to 3.78)    
Lymphatic invasion Absent 75 24.96 3.01 (2.40 to 3.77) 0.89 (0.57 to 1.37) 0.6
  Present 31 11.60 2.67 (1.88 to 3.80)    
ER positive Absent 48 13.16 3.65 (2.75 to 4.84) 0.63 (0.41 to 0.96) 0.02
  Present 46 20.16 2.28 (1.71 to 3.05)    
PR positive Absent 42 11.32 3.71 (2.75 to 5.02) 0.66 (0.43 to 1.01) 0.04
  Present 54 22.03 2.45 (1.88 to 3.20)