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Table 1 Number and percentage of index cases with each of the tumour morphology features

From: Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry

Feature All index cases Subgroup of index cases
  N = 452 % N = 375 %
Number of mitoses >50 71 15.7 33 8.8
Nuclear grade - malignant 386 85.4 316 84.3
Tubule formation <10 344 76.1 283 75.5
Syncytial pattern ≥75% 36 8.0 21 5.6
Circumscribed 93 20.6 56 14.9
Pushing margins 16 3.5 11 2.9
Lymphocytic infiltrate I - diffuse 162 35.8 136 36.3
Lymphocytic infiltrate II - intense 96 21.2 69 18.4
Glandular growth pattern 307 67.9 272 75.5
Lobular growth pattern 162 35.8 147 39.2
Trabecular growth pattern 109 24.1 65 17.3
Tubular growth pattern 74 16.4 64 17.1
Acinar growth pattern 87 19.3 60 16.0
Sclerosis - extensive 420 92.9 356 94.9
Extensive intraductal carcinoma 70 15.5 63 16.8
Necrosis 173 38.3 126 33.6
Apoptosis - moderate or intense 362 80.1 294 78.4
Lymphatic invasion 141 31.2 117 31.2
ER positive 226 56.4 201 61.1
PR positive 258 64.3 219 66.6
  1. † ER and PR status was available for 401 index cases.
  2. ‡ ER and PR status was available for 329 index cases.