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Figure 4 | Breast Cancer Research

Figure 4

From: Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis

Figure 4

Effect of retinoids on cell proliferation. Human MCF-10A, MCF-7, MDA-MB-231 and mouse Myc cells were treated for 96 h with 0.01% DMSO as control, 1 uM All-trans retinoic acid (ATRA) (retinoic acid receptor, RAR, pan-agonist), 200 nM Am580 (RARα agonist), 100 nM CD437 (RARγ and β agonist), 30 nM BMS961 (RARγ agonist), 200 nM SR11253 (RARγ antagonist), and combinations of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carboxamido]benzoic acid (Am580) with CD437, BMS961 and SR11235 at the same concentrations. Cells were counted at the end of the experiment. Results shown are representative of two independent experiments and confirmed by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) cell viability assays (not shown).

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