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Figure 1 | Breast Cancer Research

Figure 1

From: Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes

Figure 1

Gene expression identifies two distinct subtypes of breast tumor vasculature. (A) Hierarchical clustering separates normal (blue) and tumor vascular samples and segregates the tumors into two clusters (orange, magenta). Clusters in the tree are labeled with the percentage of times they were observed in 10,000 bootstrap iterations. Clinical characteristics for tumor samples: red, high/positive; white, low/negative. Tumor size is represented as a gradient from white (smallest tumor) to red (largest tumor). Clinical variables are not presented for samples from normal vasculature (left side). (B) Schematic depiction of pathways and processes differentially expressed between normal vasculature, tumor vasculature as a whole, and the two tumor vascular subtypes. Edges are labeled with the number of differentially expressed genes for each comparison. (C) Heatmap of genes differentially expressed between any two of the normal, A and B subtypes (FDR < 0.0001). Also presented are details of three functionally related groups: 1, normal vascular genes; 2, angiogenesis-inhibitor genes; and 3, classic tumor vascular genes. Heatmap colors represent Z-scores for each gene (red, high expression; green, low expression). (D) Ordering of samples by expression of pericyte markers demonstrates that these are more highly expressed in subtype B members.

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