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Table 2 Univariate and multivariate analyses of overall survival

From: Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT study

 

Univariate

Multivariate

 

P value

OR (95% CI)

P value

Menopausal status

   

Postmenopausal

Premenopausal

0.52

-

-

ER status

   

   Positive

0.26

-

-

   Negative

   

PR status

   

   Negative

0.47

-

-

   Positive

   

HER2 status

   

   Negative

0.30

-

-

   Positive

   

Metastatic site

   

   Bone

0.01

1

0.04

Visceral

 

2.6 (1.0-6.8)

0.05

Both

 

3.2 (1.3-8.2)

0.01

Number of metastatic sites

   

One site

Multiple sites

0.01

Not significant

-

Disease-free interval

   

   ≤12 months

0.12

-

-

   >12 months

   

CTC positivity

   

   <5 cells

0.00

1

<0.01

   ≥5 cells

 

2.7 (1.6-4.2)a

 

Subtype

   

   'Luminal'

0.09

1

0.02

   HER2-positive

 

0.9 (0.4-2.0)

0.84

   Triple-negative

 

2.1 (1.2-3.8)

0.00

  1. aBased on cutoff level of one circulating tumor cell (CTC): 2.06 (1.16-3.68), P < 0.05. CI, confidence interval; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; OR, odds ratio; PR, progesterone receptor.