Table 2 Overlap of genes reported as hypermethylated in variant human mammary epithelial cells and as potential prognostic epigenetic markers in breast cancer
From: Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis
Gene symbol | Methylation in vHMECs | P value of vHMECs | Methylation in immortal vHMECs | P value of immortal vHMECs | Methylation in cancer | Association in cancer |
|---|---|---|---|---|---|---|
CDO1 | NA | NA | Hyper | <0.003 | Hyper | Reduced time to distant metastasis and reduced metastasis-free survival |
CIDEB | Hyper | 0.001 | Hyper | <0.000006 | Hyper | Increased likelihood of relapse |
ESR2 (ER-B) | Hyper | 0.000002 | Hyper | <0.000009 | Hyper | Increased incidence of Relapse |
FOXL2 | NA | NA | Hyper | 0.001 | Hyper | Reduced time to distant metastasis |
ID4 | Hyper | <0.004 | Hyper | <0.004 | Hyper | Reduced recurrence-free survival |
NR2E1 | Hyper | 0.00001 | Hyper | <0.000007 | Hyper | Reduced time to distant metastasis |
OLIG2 | Hyper | <0.01 | Hyper | <0.008 | Hyper | Increased likelihood of relapse |
TLX3 | NA | NA | Hyper | <0.003 | Hyper/Hypo | Reduced time to distant metastasis |
KIF2C | Hyper | 0.004 | NA | NA | Hypo | Increased likelihood of relapse |
TOP1 | NA | NA | Hypo | 0.01 | Hypo | Increased likelihood of relapse |
VEGF | NA | NA | Hyper | 0.001 | Hypo | Increased likelihood of relapse |