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Table 2 Overlap of genes reported as hypermethylated in variant human mammary epithelial cells and as potential prognostic epigenetic markers in breast cancer

From: Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis

Gene symbol Methylation in vHMECs P value of vHMECs Methylation in immortal vHMECs P value of immortal vHMECs Methylation in cancer Association in cancer
CDO1 NA NA Hyper <0.003 Hyper Reduced time to distant metastasis and reduced metastasis-free survival
CIDEB Hyper 0.001 Hyper <0.000006 Hyper Increased likelihood of relapse
ESR2 (ER-B) Hyper 0.000002 Hyper <0.000009 Hyper Increased incidence of Relapse
FOXL2 NA NA Hyper 0.001 Hyper Reduced time to distant metastasis
ID4 Hyper <0.004 Hyper <0.004 Hyper Reduced recurrence-free survival
NR2E1 Hyper 0.00001 Hyper <0.000007 Hyper Reduced time to distant metastasis
OLIG2 Hyper <0.01 Hyper <0.008 Hyper Increased likelihood of relapse
TLX3 NA NA Hyper <0.003 Hyper/Hypo Reduced time to distant metastasis
KIF2C Hyper 0.004 NA NA Hypo Increased likelihood of relapse
TOP1 NA NA Hypo 0.01 Hypo Increased likelihood of relapse
VEGF NA NA Hyper 0.001 Hypo Increased likelihood of relapse
  1. Hyper, hypermethylation; Hypo, hypomethylation; NA, not available; vHMEC, variant human mammary epithelial cell.