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Figure 1 | Breast Cancer Research

Figure 1

From: Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer

Figure 1

Gene expression profile for the SV40/Tag signature across human breast cancer cell lines. Triple negative MDA-MB-231 cells express a genetic profile for the SV40/Tag signature similar to C3(1)/Tag tumors. Two-way hierarchical clustering uses z-score transformed expression values within each microarray dataset, one minus un-centered correlation distance metric and complete linkage. The colored bar classifies the 51 cell lines from Neve et al. [16] and new samples into breast cancer subtypes adopted from Neve et al. [16]: Luminal (blue), Basal A (red), claudin-low (orange), and normal-like (green). MB-MDA-231 cells (red box) cluster closely with C3(1)/Tag tumors and M6 cell line (blue box). Other triple negative cell lines HCC 1187, SUM 159, and BT-549 are also highlighted (green boxes).

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