TY - JOUR AU - Cortez, Valerie AU - Mann, Monica AU - Tekmal, Seshidhar AU - Suzuki, Takayoshi AU - Miyata, Naoki AU - Rodriguez-Aguayo, Cristian AU - Lopez-Berestein, Gabriel AU - Sood, Anil K. AU - Vadlamudi, Ratna K. PY - 2012 DA - 2012/07/19 TI - Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer JO - Breast Cancer Research SP - R108 VL - 14 IS - 4 AB - The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with lysine-specific histone demethylase 1 (KDM1). In this study, we assessed the therapeutic potential of targeting the PELP1-KDM1 axis in vivo using liposomal (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine; DOPC) siRNA to downregulate PELP1 expression and KDM1 inhibitors, pargyline and N-((1S)-3-(3-(trans-2-aminocyclopropyl)phenoxy)-1-(benzylcarbamoyl)propyl)benzamide using preclinical models. SN - 1465-542X UR - https://doi.org/10.1186/bcr3229 DO - 10.1186/bcr3229 ID - Cortez2012 ER -