Table 2 Associations between CD44 genotypes and five-year survival of breast cancer

rs10836347 C>T

CC

1.00 (Reference)

481 (85.0)

55

CT+TT

0.89 (0.42 to 1.88)

0.753

85 (15.0)

8

0.5854

rs1425802 A>G

AA

1.00 (Reference)

164 (29.0)

24

AG

0.63 (0.37 to 1.09)

0.102

276 (48.8)

28

0.2274

GG

0.73 (0.51 to 1.05)

0.091

126 (22.2)

11

AG+GG

0.61 (0.36 to 1.01)

0.056

402 (71.0)

39

0.0951

rs11821102 G>A

GG

1.00 (Reference)

484 (85.5)

54

AG+AA

0.93 (0.45 to 1.91)

0.845

82 (14.5)

9

0.973

rs713330 T>C

TT

1.00 (Reference)

468 (82.7)

51

CT+CC

1.14 (0.59 to 2.20)

0.676

98 (17.3)

12

0.6883

rs13347 C>T

CC

1.00 (Reference)

255 (45.1)

20

CT

1.36 (0.75 to 2.47)

0.3189

223 (39.4)

23

0.0004

TT

3.18 (1.71 to 5.91)

0.0003

88 (15.5)

20

CT+TT

1.85 (1.09 to 3.15)

0.0233

311 (54.9)

43

0.0211

Validation Set

N = 331

N = 62

rs13347 C>T

CC

1.00 (Reference)

200 (60.4)

26

CT

2.10 (1.21 to 3.65)

0.0081

100 (30.2)

25

0.0012

TT

3.14 (1.55 to 6.38)

0.0015

31 (9.4)

11

CT+TT

2.34 (1.41 to 3.88)

0.0010

131 (39.6)

36

0.0007

Pooled Analysis

N = 897

N = 125

rs13347 C>T

CC

1.00 (Reference)

455 (50.7)

46

CT

1.54 (1.02 to 2.30)

0.0378

323 (36.0)

48

< 0.0001

TT

2.84 (1.80 to 4.48)

< 0.0001

119 (13.3)

31

CT+TT

1.87 (1.30 to 2.70)

0.0007

442 (49.3)

79

0.0006