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Table 2 Associations between CD44 genotypes and five-year survival of breast cancer

From: CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations

SNPs Hazard ratio
(95% CI)
P* Breast cancer patients Death Log-rank
P
Discovery Set    N= 566 N= 63  
rs10836347 C>T      
CC 1.00 (Reference)   481 (85.0) 55  
CT+TT 0.89 (0.42 to 1.88) 0.753 85 (15.0) 8 0.5854
rs1425802 A>G      
AA 1.00 (Reference)   164 (29.0) 24  
AG 0.63 (0.37 to 1.09) 0.102 276 (48.8) 28 0.2274
GG 0.73 (0.51 to 1.05) 0.091 126 (22.2) 11  
AG+GG 0.61 (0.36 to 1.01) 0.056 402 (71.0) 39 0.0951
rs11821102 G>A      
GG 1.00 (Reference)   484 (85.5) 54  
AG+AA 0.93 (0.45 to 1.91) 0.845 82 (14.5) 9 0.973
rs713330 T>C      
TT 1.00 (Reference)   468 (82.7) 51  
CT+CC 1.14 (0.59 to 2.20) 0.676 98 (17.3) 12 0.6883
rs13347 C>T      
CC 1.00 (Reference)   255 (45.1) 20  
CT 1.36 (0.75 to 2.47) 0.3189 223 (39.4) 23 0.0004
TT 3.18 (1.71 to 5.91) 0.0003 88 (15.5) 20  
CT+TT 1.85 (1.09 to 3.15) 0.0233 311 (54.9) 43 0.0211
Validation Set    N = 331 N = 62  
rs13347 C>T      
CC 1.00 (Reference)   200 (60.4) 26  
CT 2.10 (1.21 to 3.65) 0.0081 100 (30.2) 25 0.0012
TT 3.14 (1.55 to 6.38) 0.0015 31 (9.4) 11  
CT+TT 2.34 (1.41 to 3.88) 0.0010 131 (39.6) 36 0.0007
Pooled Analysis    N = 897 N = 125  
rs13347 C>T      
CC 1.00 (Reference)   455 (50.7) 46  
CT 1.54 (1.02 to 2.30) 0.0378 323 (36.0) 48 < 0.0001
TT 2.84 (1.80 to 4.48) < 0.0001 119 (13.3) 31  
CT+TT 1.87 (1.30 to 2.70) 0.0007 442 (49.3) 79 0.0006
  1. *The Cox regression analysis was adjusted for age, BMI, family history, TNM stage, estrogen receptor status, progesterone receptor status, pathological type, menopausal status and age at menarche.