Figure 8
From: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions
Case #76: lobular carcinoma in situ and associated invasive mammary carcinoma with mixed components. (A), (B) Classic lobular carcinoma in situ (LCIS) with no membranous reactivity for E-cadherin. Residual luminal cells show membrane staining: (A) H & E, 100×; (B) E-cadherin, 100×. (C), (D) Focus of LCIS (arrows) and lobular component of the invasive mammary carcinoma (arrowheads) with no E-cadherin immunoreactivity: (C) H & E, 100×; (D) E-cadherin, 100×. (E), (F) E-cadherin-negative invasive mammary carcinoma cells (arrowheads) surrounding a normal duct concentrically in a targetoid pattern: (E) H & E, 100×; (F) E-cadherin, 40×. (G), (H) Ductal component of the invasive mammary carcinoma showing tubule formation (arrows) and strong, uniform membrane staining with E-cadherin: (G) H & E, 40×; (H) E-cadherin, 100×.