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Figure 4 | Breast Cancer Research

Figure 4

From: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions

Figure 4

Histogram of measures of similarity. Plot of the distribution of our measure of clonality for the individual comparisons of tumor pairs (red histogram). The black reference histogram is obtained by comparing all pairs of tumors from different patients. Since these pairs are definitively nonclonal they provide the reference distribution, which is used to permit calculation of the P values of the real pairings. The scale of the horizontal axis is the log-likelihood ratio (logLR), our measure of evidence in favor of clonality. The vertical axes represent the frequencies of pairs in the samples: left axis, black (reference) histogram; right axis, red (sample) histogram.

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