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Table 1 Characteristics of the cohort study of BRCA1/2 mutation carriers.

From: Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Characteristics Whole cohort One woman per family sample cohort
   All women
(N = 1337)
With BC
(N = 499)
Without BC (N = 838) All women
(N = 990)
With BC
(N = 379)
Without BC (N = 611)
   No % No % No % No % No % No %
Mutation
  BRCA1 863 64.5 332 66.5 531 63.4 635 64.1 240 63.3 395 64.6
  BRCA2 474 35.5 167 33.5 307 36.6 355 35.9 139 36.7 216 35.4
Age at interview, years             
  Mean 44.1   49.4   41.0   43.7   48.6   40.7  
  SD 0.3   0.5   0.4   0.4   0.5   0.5  
Age at diagnosis/censoring, years
  Mean 40.4   41.0   40.0   40.1   40.4   39.8  
  SD 0.3   0.4   0.4   0.3   0.5   0.5  
  <30 196 14.7 34 6.8 162 19.3 142 14.3 29 7.7 113 18.5
  30 to 39 487 36.4 205 41.1 282 33.7 371 37.5 159 42.0 212 34.7
  40 to 49 403 30.1 176 35.3 227 27.1 306 30.9 133 35.1 173 28.3
  50 to 59 180 13.5 67 13.4 113 13.5 126 12.7 47 12.4 79 12.9
  ≥60 71 5.3 17 3.4 54 6.4 45 4.5 11 2.9 34 5.6
Year of birth
  <1950 354 26.5 201 40.3 153 18.3 237 23.9 139 36.7 98 16.0
  1950 to 1959 324 24.2 165 33.1 159 19.0 248 25.1 128 33.8 120 19.6
  1960 to1969 351 26.3 119 23.8 232 27.7 282 28.5 99 26.1 183 30.0
  ≥1970 308 23.0 14 2.8 294 35.1 223 22.5 13 3.4 210 34.4
Oral contraceptive use
  Never 261 19.5 122 24.4 139 16.6 180 18.2 86 22.7 94 15.4
  Ever 1,058 79.1 373 74.7 685 81.7 798 80.6 290 76.5 508 83.1
  Missing 18 1.3 4 0.8 14 1.7 12 1.2 3 0.8 9 1.5
Number of full-term pregnancies
  0 293 21.9 68 13.6 225 26.8 217 21.9 58 15.3 159 26.0
  1 250 18.7 108 21.6 142 16.9 196 19.8 90 23.7 106 17.3
  2 452 33.8 182 36.5 270 32.2 346 34.9 139 36.7 207 33.9
  ≥3 342 25.6 141 28.3 201 24.0 231 23.3 92 24.3 139 22.7
  Missing 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0
Induced abortion
  0 1,060 79.3 383 76.8 677 80.8 776 78.4 286 75.5 490 80.2
  1 213 15.9 81 16.2 132 15.8 168 17.0 67 17.7 101 16.5
  2 44 3.3 22 4.4 22 2.6 31 3.1 15 4.0 16 2.6
  ≥3 12 0.9 8 1.6 4 0.5 9 0.9 7 1.8 2 0.3
  Missing 8 0.6 5 1.0 3 0.4 6 0.6 4 1.1 2 0.3
Spontaneous abortion
  0 1,085 81.2 387 77.6 698 83.3 791 79.9 293 77.3 498 81.5
  1 173 12.9 78 15.6 95 11.3 144 14.5 64 16.9 80 13.1
  2 50 3.7 22 4.4 28 3.3 34 3.4 12 3.2 22 3.6
  ≥3 21 1.6 8 1.6 13 1.6 16 1.6 7 1.8 9 1.5
  Missing 8 0.6 4 0.8 4 0.5 5 0.5 3 0.8 2 0.3
Breast-feeding
  Never 439 32.8 187 37.5 252 30.1 308 31.1 130 34.3 178 29.1
  Ever 568 42.5 230 46.1 338 40.3 442 44.6 182 48.0 260 42.6
  Missing 37 2.8 14 2.8 23 2.7 23 2.3 9 2.4 14 2.3
  Nulliparous 293 21.9 68 13.6 225 26.8 217 21.9 58 15.3 159 26.0
Menopausal status
  Premenopausal 1,068 79.9 404 81.0 664 79.2 795 80.3 312 82.3 483 79.1
  Postmenopausal 240 18.0 86 17.2 154 18.4 171 17.3 60 15.8 111 18.2
  Unknown 29 2.2 9 1.8 20 2.4 24 2.4 7 1.8 17 2.8
  1. BC, breast cancer; N, number; SD, standard deviation.