Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Lecarpentier, Julie; Noguès, Catherine; Mouret-Fourme, Emmanuelle; Gauthier-Villars, Marion; Lasset, Christine; Fricker, Jean-Pierre; Caron, Olivier; Stoppa-Lyonnet, Dominique; Berthet, Pascaline; Faivre, Laurence; Bonadona, Valérie; Buecher, Bruno; Coupier, Isabelle; Gladieff, Laurence; Gesta, Paul; Eisinger, François; Frénay, Marc; Luporsi, Elisabeth; Lortholary, Alain; Colas, Chrystelle; Dugast, Catherine; Longy, Michel; Pujol, Pascal; Tinat, Julie; Lidereau, Rosette; Andrieu, Nadine

doi:10.1186/bcr3218

Table 1 Characteristics of the cohort study of BRCA1/2 mutation carriers.

From: Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Characteristics		Whole cohort						One woman per family sample cohort
		All women (N = 1337)		With BC (N = 499)		Without BC (N = 838)		All women (N = 990)		With BC (N = 379)		Without BC (N = 611)
		No	%	No	%	No	%	No	%	No	%	No	%
Mutation
	BRCA1	863	64.5	332	66.5	531	63.4	635	64.1	240	63.3	395	64.6
	BRCA2	474	35.5	167	33.5	307	36.6	355	35.9	139	36.7	216	35.4
Age at interview, years
	Mean	44.1		49.4		41.0		43.7		48.6		40.7
	SD	0.3		0.5		0.4		0.4		0.5		0.5
Age at diagnosis/censoring, years
	Mean	40.4		41.0		40.0		40.1		40.4		39.8
	SD	0.3		0.4		0.4		0.3		0.5		0.5
	<30	196	14.7	34	6.8	162	19.3	142	14.3	29	7.7	113	18.5
	30 to 39	487	36.4	205	41.1	282	33.7	371	37.5	159	42.0	212	34.7
	40 to 49	403	30.1	176	35.3	227	27.1	306	30.9	133	35.1	173	28.3
	50 to 59	180	13.5	67	13.4	113	13.5	126	12.7	47	12.4	79	12.9
	≥60	71	5.3	17	3.4	54	6.4	45	4.5	11	2.9	34	5.6
Year of birth
	<1950	354	26.5	201	40.3	153	18.3	237	23.9	139	36.7	98	16.0
	1950 to 1959	324	24.2	165	33.1	159	19.0	248	25.1	128	33.8	120	19.6
	1960 to1969	351	26.3	119	23.8	232	27.7	282	28.5	99	26.1	183	30.0
	≥1970	308	23.0	14	2.8	294	35.1	223	22.5	13	3.4	210	34.4
Oral contraceptive use
	Never	261	19.5	122	24.4	139	16.6	180	18.2	86	22.7	94	15.4
	Ever	1,058	79.1	373	74.7	685	81.7	798	80.6	290	76.5	508	83.1
	Missing	18	1.3	4	0.8	14	1.7	12	1.2	3	0.8	9	1.5
Number of full-term pregnancies
	0	293	21.9	68	13.6	225	26.8	217	21.9	58	15.3	159	26.0
	1	250	18.7	108	21.6	142	16.9	196	19.8	90	23.7	106	17.3
	2	452	33.8	182	36.5	270	32.2	346	34.9	139	36.7	207	33.9
	≥3	342	25.6	141	28.3	201	24.0	231	23.3	92	24.3	139	22.7
	Missing	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0
Induced abortion
	0	1,060	79.3	383	76.8	677	80.8	776	78.4	286	75.5	490	80.2
	1	213	15.9	81	16.2	132	15.8	168	17.0	67	17.7	101	16.5
	2	44	3.3	22	4.4	22	2.6	31	3.1	15	4.0	16	2.6
	≥3	12	0.9	8	1.6	4	0.5	9	0.9	7	1.8	2	0.3
	Missing	8	0.6	5	1.0	3	0.4	6	0.6	4	1.1	2	0.3
Spontaneous abortion
	0	1,085	81.2	387	77.6	698	83.3	791	79.9	293	77.3	498	81.5
	1	173	12.9	78	15.6	95	11.3	144	14.5	64	16.9	80	13.1
	2	50	3.7	22	4.4	28	3.3	34	3.4	12	3.2	22	3.6
	≥3	21	1.6	8	1.6	13	1.6	16	1.6	7	1.8	9	1.5
	Missing	8	0.6	4	0.8	4	0.5	5	0.5	3	0.8	2	0.3
Breast-feeding
	Never	439	32.8	187	37.5	252	30.1	308	31.1	130	34.3	178	29.1
	Ever	568	42.5	230	46.1	338	40.3	442	44.6	182	48.0	260	42.6
	Missing	37	2.8	14	2.8	23	2.7	23	2.3	9	2.4	14	2.3
	Nulliparous	293	21.9	68	13.6	225	26.8	217	21.9	58	15.3	159	26.0
Menopausal status
	Premenopausal	1,068	79.9	404	81.0	664	79.2	795	80.3	312	82.3	483	79.1
	Postmenopausal	240	18.0	86	17.2	154	18.4	171	17.3	60	15.8	111	18.2
	Unknown	29	2.2	9	1.8	20	2.4	24	2.4	7	1.8	17	2.8

BC, breast cancer; N, number; SD, standard deviation.

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