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Table 6 Local positive, TMA negative results (n = 13)

From: Determining sensitivity and specificity of HER2 testing in breast cancer using a tissue micro-array approach

No. of cases Local result Revision local result TMA result Full-sized 4B5, SP3, monocolor-SISH result Conclusion
4 2+, ISH+ 2+, ISH+ No amplification 2+, 2+, no amplification Local -ISH procedure unreliable
1 3+ 3+ No amplification 3+, 3+ no amplification Overexpression without amplification
2 3+ 3+ No amplification 2+, 2+ no amplification Local IHC procedure unreliable
1 3+ 2-3+ No amplification 2-3+, 2+, no amplification Local IHC scoring unreliable
3 3+ 2+ No amplification 1-2+, 1-2+, no amplification Local IHC scoring unreliable
2 2+, ISH+ 2+, ISH - No amplification 2+, 2 no amplification Local -ISH scoring unreliable
  1. IHC, immunohistochemistry; ISH, in situ hybridization; SISH silver in situ hybridization; TMA, tissue micro-array.