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Table 6 Local positive, TMA negative results (n = 13)

From: Determining sensitivity and specificity of HER2 testing in breast cancer using a tissue micro-array approach

No. of cases

Local result

Revision local result

TMA result

Full-sized 4B5, SP3, monocolor-SISH result

Conclusion

4

2+, ISH+

2+, ISH+

No amplification

2+, 2+, no amplification

Local -ISH procedure unreliable

1

3+

3+

No amplification

3+, 3+ no amplification

Overexpression without amplification

2

3+

3+

No amplification

2+, 2+ no amplification

Local IHC procedure unreliable

1

3+

2-3+

No amplification

2-3+, 2+, no amplification

Local IHC scoring unreliable

3

3+

2+

No amplification

1-2+, 1-2+, no amplification

Local IHC scoring unreliable

2

2+, ISH+

2+, ISH -

No amplification

2+, 2 no amplification

Local -ISH scoring unreliable

  1. IHC, immunohistochemistry; ISH, in situ hybridization; SISH silver in situ hybridization; TMA, tissue micro-array.