MMR status and TSG methylation in eight different tumor types from mutation carriers. A, for MMR status comparisons, the frequencies of MSI and abnormal IHC in the same tumors are indicated. B, Among TSGs, the top five loci affected by methylation in breast cancer were chosen for display. Dm >0.25 was used as a cut-off for methylation for all tumors. The average number of methylated TSGs out of 24 per tumor is given below each tumor type. Dm, methylation dosage ratio; IHC, immunohistochemistry; MMR, mismatch repair; MSI, microsatellite instability; TSG, tumor suppressor gene.