Figure 2

TSG methylation profiles in breast tumors from MMR gene mutation carriers, non-carriers and sporadic cases. Breast carcinomas from MMR gene mutation carriers and non-carriers were mostly ductal (Table 1) whereas sporadic cases were divided into ductal and lobular subgroups. Only TSGs which showed promoter methylation in at least 10% of tumors from any group (carriers, non-carriers, sporadic) were included in this comparison. MMR, mismatch repair; TSG, tumor suppressor gene.