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Figure 5 | Breast Cancer Research

Figure 5

From: Invasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling

Figure 5

Integrin β4 neoexpression induces Rac1 activation. Akt phosphorylation and Rac1 activation is shown in (A) wild-type and (B) integrin β4-expressing fibroblasts. Wild-type and integrin β4-expressing fibroblasts were incubated in RSM, MCF7 CM, or MDA-MB-231 CM under anoikis conditions for 24 hours. Suspended fibroblasts were harvested for Rac1 pull-down assays.

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