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Figure 4 | Breast Cancer Research

Figure 4

From: Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo

Figure 4

Effects of plakoglobin expression on tumor cell invasion, migration, and expression of the tumor-suppressor gene NM23-H1. (A, B) Histograms of mean ± SEM percentage of MCF7 (A) and T47D (B) tumor cell invasion through a basement membrane matrix (Matrigel)-coated membrane compared with an uncoated membrane. Histograms showing mean ± SEM percentage of wound closure by MCF7 cells 24, 48, and 72 hours after scratch (C), and T47D cells 24 and 48 hours after scratch (D). (E) Expression of the tumor-suppressor gene, NM23-H1, in control and plakoglobin-knockdown MCF7 and T47D cells. (*P < 0.005, by one-way ANOVA followed by the Dunnett two-sided multiple-comparison test).

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Breast Cancer Research

ISSN: 1465-542X

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