From: The interaction between ER and NFκB in resistance to endocrine therapy
Endocrine therapeutic | Mechanism | Examples |
---|---|---|
Selective estrogen receptor modulator | Competitive inhibitor of estrogen receptor; antagonistic and agonistic effects | Tamoxifen, raloxifen, toremifine, droloxifene, idoxifene, arzoxifene, LY117018 |
Selective estrogen receptor downregulator | Competitive inhibitor of estrogen receptor; promotes degradation of estrogen receptor | ICI182780, ICI164384, RU58668 |
Aromatase inhibitor | Inhibitor of estrogen synthesis | Letrozole, anastrozole, exemestan |