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Table 1 Overview of endocrine therapeutics and their mechanisms of action

From: The interaction between ER and NFκB in resistance to endocrine therapy

Endocrine therapeutic Mechanism Examples
Selective estrogen receptor modulator Competitive inhibitor of estrogen receptor; antagonistic and agonistic effects Tamoxifen, raloxifen, toremifine, droloxifene, idoxifene, arzoxifene, LY117018
Selective estrogen receptor downregulator Competitive inhibitor of estrogen receptor; promotes degradation of estrogen receptor ICI182780, ICI164384, RU58668
Aromatase inhibitor Inhibitor of estrogen synthesis Letrozole, anastrozole, exemestan