Table 1 Comparison of the canonical pathways

Comparison A: Wt MCF7+E2 versus week 1

Comparison A: Wt MCF7+E2 versus week 1

Interferon signalling

2.79 E-07

Purine metabolism

1.13 E-12

Molecular mechanisms of cancer

1.17 E-05

Pyrimidine metabolism

2.11 E-10

JAK/STAT signalling

2.72 E-05

Protein ubiquitination pathway

6.48 E-08

Germ cell-steroli cell junction signalling

2.76 E-05

Role of BRCA1 in DNA damage response

6.92 E-08

Inositol phosphate metabolism

1.15 E-04

Mitotic roles of polo-like kinase

5.72 E-07

IL-3 signalling

1.63 E-04

Role of CHK proteins in cell cycle checkpoint control

1.41 E-06

PDGF signalling

1.94 E-04

ATM signalling

3.06 E-06

Neuregulin signalling

2.15 E-04

Cell cycle:G2/M DNA damage checkpoint regulation

1.23 E-05

Erythropoietin signalling

2.31 E-04

Cleavage and polyadenylation of pre-mRNA

1.24 E-04

PI3K/AKT signalling

2.95 E-05

Alanine and aspartate metabolism

5.15 E-04

Comparison B: Week 1 versus week 9

Comparison B: Week 1 versus week 9

Mitotic roles of polo-like kinase

4.71E-08

Antigen presentation pathway

8.88E-20

Role of CHK proteins in cell cycle checkpoint control

2.08E-07

Interferon signalling

1.44E-17

ATM signalling

3.27E-07

Activation of IRF by cytosolic pattern recognition receptors

2.48E-10

Role of BRCA1 in DNA damage and response

8.75E-06

Role of pattern recognition receptors in recognition of bacteria and viruses

2.37E-07

Hereditary breast cancer signalling

2.08E-05

Dendritic cell maturation

3.54E-06

Pyrimidine metabolism

3.34E-05

Allograft rejection signalling

7.64E-06

Cell cycle: G2/M DNA damage checkpoint regulation

1.57E-04

Autoimmune thyroid disease signalling

1.04E-05

Graft-versus-host disease signalling

1.21E-05

Role of RIG1-like receptors in antiviral innate immunity

1.39E-05

Cross talk between dendritic cells and natural killer cells

2.02E-05

Comparison C: Wt MCF7+E2 versus week 9

Comparison C: Wt MCF7+E2 versus week 9

PDGF signalling

1.15E-07

Protein ubiquitination pathway

1.63 E-07

Molecular mechanisms of cancer

1.53E-07

Purine metabolism

6.49 E-07

Actin cytoskeleton signalling

4.92E-07

Pyrimidine metabolism

7.92 E-06

Integrin signalling

6.93E-07

Mitochondrial dysfunction

1.25 E-04

PI3K/AKT signalling

1.06E-06

Oxidative phosphorylation

2.47 E-04

EGF signalling

5.88E-06

Citrate cycle

4.79 E-04

FAK signalling

8.45E-06

Role of BRCA1 in DNA damage response

7.53 E-04

HGF signalling

1.23E-05

Lysine degradation

7.84 E-04

14-3-3 mediated signalling

1.30E-05

Neuregulin signalling

1.53E-05

Ephrin Receptor Signaling

1.66E-05

IGF-1 Signaling

1.85E-05

ILK Signaling

2.27E-05

Axonal Guidance Signaling

3.12E-05

JAK/Stat Signaling

6.14E-05

Insulin Receptor Signaling

6.17E-05