Figure 1

Activation of TAZ upon epithelial-to-mesenchymal transition in human breast cancer cells. A schematic of components of the mammalian Hippo pathway in epithelial (left) and mesenchymal-like (right) states of breast cancer cells. Components addressed by Cordenonsi and colleagues are shown in red. The authors demonstrated that Scribble is delocalized from the plasma membrane upon epithelial-to-mesenchymal transition (EMT), leading to stabilization of the TAZ protein and its translocation to the nucleus, where it activates downstream targets. Question marks indicate open questions.